Rr387 Other Genome Feature Detail

Summary

• Symbol
  Rr387
• Name
  regulatory region 387
• Synonyms
  E0

• Feature Type
  enhancer
• IDs
  MGI:7440031

Location &
Maps

• Sequence Map
  Chr6:64709990-64712013 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• J:332270 deletion coordinates: chr6:64,733,006-64,735,029 (mm10) chr6:64709990-64712013 (GRCm39)

• Genetic Map
  Chromosome 6, Syntenic

Strain
Comparison

• SNPs within 2kb
  119 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 1 allele in 1 genetic background
  8 phenotypes from multigenic genotypes
  2 phenotype references
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  0 strains or lines available

Homozygous deletion of this Atoh1 enhancer doesn't lead to a hearing phenotype but does affect cerebellar development and impairs balance.

References

• Summaries
  All 4

  Phenotypes 2
• Earliest
  J:60854 Helms AW, et al., Autoregulation and multiple enhancers control Math1 expression in the developing nervous system. Development. 2000 Mar;127(6):1185-96
• Latest
  J:333396 Luo Z, et al., Three distinct Atoh1 enhancers cooperate for sound receptor hair cell development. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2119850119