Rr439 Other Genome Feature Detail

Summary

• Symbol
  Rr439
• Name
  regulatory region 439
• Synonyms
  Sox-2 regulatory region, Srr2

• Feature Type
  enhancer
• IDs
  MGI:7495581
• Regulates expression of
  Sox2 (1 regulated gene)

Location &
Maps

• Sequence Map
  Chr3:34708174-34708233 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• 4kb downstream of Sox2 (UCSC mm9 genome chr3:34,552,926-34,553,007) chr3:34708153-34708234 (GRCm39) PMID:12136102 sequence AAGAATTTCCCGGGCTCGGGCAGCCATTGTGATGCATATAGGATTATTCACGTGGTAATG chr3:34708174-34708233 (GRCm39)

• Genetic Map
  Chromosome 3, Syntenic

Strain
Comparison

• SNPs within 2kb
  47 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 2

  Phenotypes 1
• Earliest
  J:337515 Miyagi S, et al., The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells. Mol Cell Biol. 2004 May;24(10):4207-20
• Latest
  J:302308 Moncho-Amor V, et al., SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in p27-null mice. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2017115118

Rr439 regulates expression of:

Feature	Feature Type	Location	Reference
Sox2, SRY (sex determining region Y)-box 2	protein coding gene	Chr3:34704554-34706610 (+)	J:337515