Zc3h7ait Gene Detail

Summary

• Symbol
  Zc3h7ait
• Name
  zinc finger CCCH type containing 7 A intronic transcript
• Synonyms
  Lnczc3h7a

• Feature Type
  lncRNA gene
• IDs
  MGI:7571620
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 16, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  11 phenotypes from 1 allele in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a null allele exhibit impaired antiviral innate immune responses to RNA viruses and show decreased serum levels of type I IFNs and IL-6, more severe lung pathology, increased viral replication, and accelerated lethality in response to vesicular stomatitis virus infection.

References

• Summaries
  All 2

  Phenotypes 1
• Earliest
  J:282488 Lin H, et al., The long noncoding RNA Lnczc3h7a promotes a TRIM25-mediated RIG-I antiviral innate immune response. Nat Immunol. 2019 Jul;20(7):812-823