Rr499 Other Genome Feature Detail

Summary

• Symbol
  Rr499
• Name
  regulatory region 499
• Synonyms
  Ptf1a 5' enhancer

• Feature Type
  enhancer
• IDs
  MGI:7704144
• Cluster Member
  Rr41803 (1 member)
• Regulates expression of
  Ptf1a (1 regulated gene)

Location &
Maps

• Sequence Map
  Chr2:19434901-19437198 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• J:139869 location: chr2:19347844-19350141 (mm8) chr2:19434901-19437198 (GRCm39)

• Genetic Map
  Chromosome 2, Syntenic

Strain
Comparison

• SNPs within 2kb
  149 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  5
• Endonuclease-mediated
  5
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:139869 Masui T, et al., Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood. Mol Cell Biol. 2008 Sep;28(17):5458-68
• Latest
  J:297165 Mona B, et al., Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons. Genes Dev. 2020 May 1;34(9-10):621-636

Rr499 regulates expression of:

Feature	Feature Type	Location	Reference
Ptf1a, pancreas specific transcription factor, 1a	protein coding gene	Chr2:19450474-19452312 (+)	J:139869

Rr499 Cluster contains:

More Data for these features

Member	Feature Type	Location
Rr41803, regulatory region 41803	CTCF binding site	Chr2:19436001-19436200