Rr588 Other Genome Feature Detail

Summary

• Symbol
  Rr588
• Name
  regulatory region 588
• Synonyms
  C24-DS1, Cyp24a1-DS1

• Feature Type
  enhancer
• IDs
  MGI:7790794
• Cluster Members
  Rr47973, Rr47974, Rr41025 ... (5 members)
• Regulates expression of
  Cyp24a1 (1 regulated gene)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.
• chr2:170303959-170321421 (GRCm39)

• Genetic Map
  Chromosome 2, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Endonuclease-mediated
  1
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:360044 Meyer MB, et al., A downstream intergenic cluster of regulatory enhancers contributes to the induction of CYP24A1 expression by 1alpha,25-dihydroxyvitamin D3. J Biol Chem. 2010 May 14;285(20):15599-15610
• Latest
  J:359838 Meyer MB, et al., A chromatin-based mechanism controls differential regulation of the cytochrome P450 gene Cyp24a1 in renal and non-renal tissues. J Biol Chem. 2019 Sep 27;294(39):14467-14481

Rr588 regulates expression of:

Feature	Feature Type	Location	Reference
Cyp24a1, cytochrome P450, family 24, subfamily a, polypeptide 1	protein coding gene	Chr2:170324877-170339065 (-)	J:359838

Rr588 Cluster contains:

More Data for these features

Member	Feature Type	Location
Rr47973, regulatory region 47973	enhancer	Chr2:170304401-170304600
Rr47974, regulatory region 47974	enhancer	Chr2:170307001-170307200
Rr41025, regulatory region 41025	CTCF binding site	Chr2:170310001-170310400
Rr41026, regulatory region 41026	CTCF binding site	Chr2:170316401-170316600
Rr41027, regulatory region 41027	CTCF binding site	Chr2:170318001-170318600