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Abl1 Gene Detail
Summary
  • Symbol
    Abl1
  • Name
    c-abl oncogene 1, non-receptor tyrosine kinase
  • Synonyms
    c-Abl, E430008G22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:87859
    NCBI Gene: 11350
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:31578388-31694239 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.86 cM, cytoband B
  • Mapping Data
    55 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2374 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87859
 protein coding gene Chr2:31578256-31697105 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025589
 protein coding gene Chr2:30047193-30183001 (+)
A/J MGP_AJ_G0025567
 protein coding gene Chr2:28807505-28932795 (+)
AKR/J MGP_AKRJ_G0025536
 protein coding gene Chr2:29786693-29927623 (+)
BALB/cJ MGP_BALBcJ_G0025563
 protein coding gene Chr2:28938064-29059960 (+)
C3H/HeJ MGP_C3HHeJ_G0025324
 protein coding gene Chr2:29715418-29841478 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026008
 protein coding gene Chr2:30990471-31125186 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023416
 protein coding gene Chr2:27564487-27677473 (+)
CAST/EiJ MGP_CASTEiJ_G0024786
 protein coding gene Chr2:29659467-29784750 (+)
CBA/J MGP_CBAJ_G0025301
 protein coding gene Chr2:32101781-32252813 (+)
DBA/2J MGP_DBA2J_G0025434
 protein coding gene Chr2:28582488-28706744 (+)
FVB/NJ MGP_FVBNJ_G0025397
 protein coding gene Chr2:28440445-28556670 (+)
LP/J MGP_LPJ_G0025520
 protein coding gene Chr2:29936732-30056888 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025427
 protein coding gene Chr2:31860458-31991498 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026066
 protein coding gene Chr2:29710761-29842418 (+)
PWK/PhJ MGP_PWKPhJ_G0024533
 protein coding gene Chr2:28481689-28597298 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024333
 protein coding gene Chr2:29857476-29980766 (+)
WSB/EiJ MGP_WSBEiJ_G0024854
 protein coding gene Chr2:29882181-30017094 (+)



Homology
more
  • Human Ortholog
    ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase
  • Synonyms
    ABL, bcr/abl, BCR-ABL, c-ABL, c-ABL1, CHDSKM, JTK7, p150, v-abl
  • Links
    NCBI Gene ID: 25
    neXtProt AC: NX_P00519
    UniProt: P00519

  • Chr Location
    9q34.12; chr9:130713043-130887675 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human ABL1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    78 phenotypes from 11 alleles in 13 genetic backgrounds
    37 phenotypes from multigenic genotypes
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene have increased perinatal and postnatal mortality and may display foreshortened crania, abnormal development of spleen, head, heart and eye, reduced B and T cell populations, and osteoporosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    256
  • GO References
    62
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    981
  • Tissues
    137
  • cDNA Data
    223
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026842 Ensembl Gene Model | MGI Sequence Detail 115852 C57BL/6J ±  kb
    transcript ENSMUST00000075759 Ensembl | MGI Sequence Detail 6327 Not Applicable  
    polypeptide ENSMUSP00000075167 Ensembl | MGI Sequence Detail 1142 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 249
      Genomic 14
      cDNA 224
      Primer pair 2
      Other 9

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1015, MGI:2138905, MGI:2443781
    References
    more
    • Summaries
      All 290
      Developmental Gene Expression 27
      Gene Ontology 62
      Phenotypes 82
    • Earliest
      J:6037 Risser R, et al., Abelson antigen: a viral tumor antigen that is also a differentiation antigen of BALB/c mice. Proc Natl Acad Sci U S A. 1978 Aug;75(8):3918-22
    • Latest
      J:349813 Chandia-Cristi A, et al., Prophylactic treatment with the c-Abl inhibitor, neurotinib, diminishes neuronal damage and the convulsive state in pilocarpine-induced mice. Cell Rep. 2024 May 28;43(5):114144
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory