Abl2 MGI Mouse Gene Detail - MGI:87860 - ABL proto-oncogene 2, non-receptor tyrosine kinase

Symbol

Abl2
Name

ABL proto-oncogene 2, non-receptor tyrosine kinase
Synonyms

Abll, Arg

Feature Type

protein coding gene
IDs

MGI:87860
NCBI Gene: 11352
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:156386356-156477138 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 67.71 cM
Mapping Data

6 experiments

SNPs within 2kb

2054 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87860	protein coding gene	Chr1:156386160-156477189 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016625	protein coding gene	Chr1:161521916-161616484 (+)
A/J	MGP_AJ_G0016606	protein coding gene	Chr1:155028905-155123980 (+)
AKR/J	MGP_AKRJ_G0016572	protein coding gene	Chr1:159755868-159856443 (+)
BALB/cJ	MGP_BALBcJ_G0016567	protein coding gene	Chr1:155525519-155617681 (+)
C3H/HeJ	MGP_C3HHeJ_G0016391	protein coding gene	Chr1:159887574-159984801 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017028	protein coding gene	Chr1:167047589-167149537 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014737	protein coding gene	Chr1:147224956-147319253 (+)
CAST/EiJ	MGP_CASTEiJ_G0015971	protein coding gene	Chr1:159437838-159535108 (+)
CBA/J	MGP_CBAJ_G0016366	protein coding gene	Chr1:172944033-173058694 (+)
DBA/2J	MGP_DBA2J_G0016472	protein coding gene	Chr1:153975729-154070255 (+)
FVB/NJ	MGP_FVBNJ_G0016470	protein coding gene	Chr1:152437320-152528621 (+)
LP/J	MGP_LPJ_G0016543	protein coding gene	Chr1:162652083-162745292 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016495	protein coding gene	Chr1:180487813-180584871 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017064	protein coding gene	Chr1:159572683-159669078 (+)
PWK/PhJ	MGP_PWKPhJ_G0015757	protein coding gene	Chr1:153071866-153164918 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015544	protein coding gene	Chr1:158313975-158419021 (+)
WSB/EiJ	MGP_WSBEiJ_G0016033	protein coding gene	Chr1:159675157-159773053 (+)

Human Ortholog

ABL2, ABL proto-oncogene 2, non-receptor tyrosine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ABL2, ABL proto-oncogene 2, non-receptor tyrosine kinase
Synonyms

ABLL, ARG
Links

HGNC:77

NCBI Gene ID: 27

neXtProt AC: NX_P42684

UniProt: P42684
Chr Location

1q25.2; chr1:179099330-179229684 (-) GRCh38

MGI Vertebrate Homology

Abl2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ABL2
Gene Tree

Abl2

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Phenotype Summary

11 phenotypes from 2 alleles in 3 genetic backgrounds
33 phenotypes from multigenic genotypes
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

52
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

44
Targeted

5
Genomic Mutations

2 involving Abl2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

80 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for targeted mutations that inactivate the gene display multiple behavioral abnormalities indicating neuronal defects.

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All GO Annotations

98
GO References

27

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

803
Tissues

21
cDNA Data

15
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase abl2

ZFIN abl2

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All Sequences

79
RefSeq

24
UniProt

8
CCDS

CCDS15393.1, CCDS48404.1

Ensembl

ENSMUSG00000026596 (Evidence)
NCBI Gene

11352

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026596	Ensembl Gene Model \| MGI Sequence Detail	90783	C57BL/6J	± kb
transcript	ENSMUST00000027888	Ensembl \| MGI Sequence Detail	3549	Not Applicable
polypeptide	ENSMUSP00000027888	Ensembl \| MGI Sequence Detail	1182	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000003583 tyrosine-protein kinase ABL2

(term hierarchy)
PDB

4XLI
EC

2.7.10.2
InterPro Domains

IPR015015 F-actin binding

IPR043539 Grb2-like

IPR050198 Non-receptor tyrosine kinases involved in cell signaling

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR035837 Tyrosine-protein kinase ABL, SH2 domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain
GlyGen

Q4JIM5 5 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (3 sites)

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All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 5

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MGD-MRK-1016, MGD-MRK-1391, MGI:2138109

Summaries

All 95

Developmental Gene Expression 10

Gene Ontology 27

Phenotypes 32
Earliest

J:8517 Kruh GD, et al., A novel human gene closely related to the abl proto-oncogene. Science. 1986 Dec 19;234(4783):1545-8
Latest

J:327184 Xiao Z, et al., The Maternal Microbiome Programs the m(6)A Epitranscriptome of the Mouse Fetal Brain and Intestine. Front Cell Dev Biol. 2022;10:882994

TSS for Abl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9570	Chr1:156386329-156386376 (+)	-3 bp
Tssr9571	Chr1:156386414-156386439 (+)	71 bp
Tssr9572	Chr1:156443388-156443432 (+)	57,054 bp
Tssr9573	Chr1:156443447-156443456 (+)	57,096 bp
Tssr9574	Chr1:156443473-156443503 (+)	57,132 bp
Tssr9575	Chr1:156461605-156461609 (+)	75,251 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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