About   Help   FAQ
Acat2 Gene Detail
Summary
  • Symbol
    Acat2
  • Name
    acetyl-Coenzyme A acetyltransferase 2
  • Synonyms
    Tcp1-rs1, Tcp-1x
  • Feature Type
    protein coding gene
  • IDs
    MGI:87871
    NCBI Gene: 110460
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:13161929-13179612 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.73 cM, cytoband A2-A3
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    456 from dbSNP Build 142
  • Strain Annotations
    13
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87871
 protein coding gene Chr17:13161777-13179634 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023156
 protein coding gene Chr17:10618104-10646367 (-)
A/J MGP_AJ_G0023124
 protein coding gene Chr17:10448875-10467463 (-)
AKR/J MGP_AKRJ_G0023088
 protein coding gene Chr17:10288496-10304280 (-)
BALB/cJ MGP_BALBcJ_G0023124
 protein coding gene Chr17:10233973-10252635 (-)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0021041
 protein coding gene Chr17:3990107-4007255 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0022859
 protein coding gene Chr17:11436171-11468835 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0022962
 protein coding gene Chr17:10018736-10039678 (-)
LP/J MGP_LPJ_G0023063
 protein coding gene Chr17:10487693-10500838 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022981
 protein coding gene Chr17:11088634-11092864 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023593
 protein coding gene Chr17:10554787-10581902 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0021979
 protein coding gene Chr17:9983436-10002730 (-)
WSB/EiJ MGP_WSBEiJ_G0022458
 protein coding gene Chr17:10875179-10899446 (-)



Homology
more
  • Human Ortholog
    ACAT2, acetyl-CoA acetyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACAT2, acetyl-CoA acetyltransferase 2
  • Links
    NCBI Gene ID: 39
    neXtProt AC: NX_Q9BWD1
    UniProt: Q9BWD1

  • Chr Location
    6q25.3; chr6:159762045-159779112 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ACAT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1061
  • Tissues
    153
  • cDNA Data
    13
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110460 NCBI Gene Model | MGI Sequence Detail 17684 C57BL/6J ±  kb
    transcript NM_009338 RefSeq | MGI Sequence Detail 2076 ZRU/MplStud  
    polypeptide Q8CAY6 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 5
      cDNA 15
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1029, MGD-MRK-14817, MGD-MRK-14828, MGI:2147098, MGI:98537
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:8190 Willison KR, et al., Molecular cloning and sequence analysis of a haploid expressed gene encoding t complex polypeptide 1. Cell. 1986 Mar 14;44(5):727-38
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory