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Ace Gene Detail
Summary
  • Symbol
    Ace
  • Name
    angiotensin I converting enzyme
  • Synonyms
    CD143
  • Feature Type
    protein coding gene
  • IDs
    MGI:87874
    NCBI Gene: 11421
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:105858774-105880790 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 68.84 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    538 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87874
 protein coding gene Chr11:105858771-105880790 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019288
 protein coding gene Chr11:109234278-109257791 (+)
A/J MGP_AJ_G0019256
 protein coding gene Chr11:104589333-104610930 (+)
AKR/J MGP_AKRJ_G0019225
 protein coding gene Chr11:107712236-107735979 (+)
BALB/cJ MGP_BALBcJ_G0019230
 protein coding gene Chr11:104993314-105015443 (+)
C3H/HeJ MGP_C3HHeJ_G0019039
 protein coding gene Chr11:108005982-108028584 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019680
 protein coding gene Chr11:112589859-112613898 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017305
 protein coding gene Chr11:101880015-101901439 (+)
CAST/EiJ MGP_CASTEiJ_G0018592
 protein coding gene Chr11:109055386-109079503 (+)
CBA/J MGP_CBAJ_G0019008
 protein coding gene Chr11:117277000-117301247 (+)
DBA/2J MGP_DBA2J_G0019120
 protein coding gene Chr11:104064547-104086368 (+)
FVB/NJ MGP_FVBNJ_G0019111
 protein coding gene Chr11:103568038-103590303 (+)
LP/J MGP_LPJ_G0019190
 protein coding gene Chr11:109688724-109712120 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019141
 protein coding gene Chr11:116570951-116598788 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019717
 protein coding gene Chr11:108196014-108217538 (+)
PWK/PhJ MGP_PWKPhJ_G0018357
 protein coding gene Chr11:105156672-105179568 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018148
 protein coding gene Chr11:107966872-107992726 (+)
WSB/EiJ MGP_WSBEiJ_G0018643
 protein coding gene Chr11:108168464-108191086 (+)



Homology
more
  • Human Ortholog
    ACE, angiotensin I converting enzyme
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACE, angiotensin I converting enzyme
  • Synonyms
    ACE1, CD143, DCP, DCP1
  • Links
    NCBI Gene ID: 1636
    neXtProt AC: NX_P12821
    UniProt: P12821

  • Chr Location
    17q23.3; chr17:63477061-63498380 (+)  GRCh38
Human Diseases
more
  • Diseases
    45 with human ACE associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    78 phenotypes from 12 alleles in 11 genetic backgrounds
    34 phenotypes from multigenic genotypes
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a number of different targeted mutations show variable phenotypes, including reduced systemic blood pressure, normocytic anemia, renal abnormalities, inability to concentrate urine, and reduced male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    141
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1017
  • Tissues
    151
  • cDNA Data
    25
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11421 NCBI Gene Model | MGI Sequence Detail 22017 C57BL/6J ±  kb
    transcript NM_001281819 RefSeq | MGI Sequence Detail 5088 ZRU/MplStud  
    polypeptide P09470 UniProt | EBI | MGI Sequence Detail 1312 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 6
      cDNA 26
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1032, MGI:2144508
    References
    more
    • Summaries
      All 184
      Developmental Gene Expression 22
      Gene Ontology 23
      Phenotypes 89
    • Earliest
      J:21460 Bernstein KE, et al., The isolation of angiotensin-converting enzyme cDNA. J Biol Chem. 1988 Aug 15;263(23):11021-4
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory