Acp1 MGI Mouse Gene Detail - MGI:87881 - acid phosphatase 1, soluble

Symbol

Acp1
Name

acid phosphatase 1, soluble
Synonyms

4632432E04Rik, Acp-1, Lmptp, LMW-PTP

Feature Type

protein coding gene
IDs

MGI:87881
NCBI Gene: 11431
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr12:30943325-30961588 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 13.00 cM
Mapping Data

4 experiments

SNPs within 2kb

503 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87881	protein coding gene	Chr12:30943325-30961616 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019654	protein coding gene	Chr12:28811890-28834004 (-)
A/J	MGP_AJ_G0019621	protein coding gene	Chr12:28005698-28024601 (-)
AKR/J	MGP_AKRJ_G0019592	protein coding gene	Chr12:28908278-28927602 (-)
BALB/cJ	MGP_BALBcJ_G0019598	protein coding gene	Chr12:28249524-28269983 (-)
C3H/HeJ	MGP_C3HHeJ_G0019402	protein coding gene	Chr12:28772175-28793507 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020045	protein coding gene	Chr12:29707099-29726968 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017670	protein coding gene	Chr12:27326929-27345325 (-)
CAST/EiJ	MGP_CASTEiJ_G0018957	protein coding gene	Chr12:23773436-23791541 (-)
CBA/J	MGP_CBAJ_G0019373	protein coding gene	Chr12:30678157-30701748 (-)
DBA/2J	MGP_DBA2J_G0019487	protein coding gene	Chr12:27840666-27865343 (-)
FVB/NJ	MGP_FVBNJ_G0019478	protein coding gene	Chr12:27641907-27659055 (-)
LP/J	MGP_LPJ_G0019557	protein coding gene	Chr12:28904959-28932544 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019513	protein coding gene	Chr12:30307243-30325771 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020085	protein coding gene	Chr12:28428377-28447607 (-)
PWK/PhJ	MGP_PWKPhJ_G0018724	protein coding gene	Chr12:22579150-22598379 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018512	protein coding gene	Chr12:23050138-23068712 (-)
WSB/EiJ	no annotation

Human Ortholog

ACP1, acid phosphatase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACP1, acid phosphatase 1
Synonyms

HAAP, LMW-PTP, LMWPTP
Links

HGNC:122

NCBI Gene ID: 52

neXtProt AC: NX_P24666

UniProt: P24666
Chr Location

2p25.3; chr2:264140-278283 (+) GRCh38

MGI Vertebrate Homology

Acp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACP1
Gene Tree

Acp1

Diseases

8 with human ACP1 associations

				Human Disease	Mouse Models
				attention deficit hyperactivity disorder IDs attention deficit hyperactivity disorder DOID:1094 DOID:1093 EFO:0003888 ICD9CM:314.8 MESH:D001289 OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312 UMLS_CUI:C0041671
				conduct disorder IDs conduct disorder DOID:12995 EFO:0004216 ICD10CM:F91 ICD9CM:312.9 MESH:D019955 NCI:C89329 UMLS_CUI:C0149654
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				diabetes mellitus IDs diabetes mellitus DOID:9351 ICD10CM:E08-E13 ICD9CM:250 MESH:D003920 NCI:C2985 UMLS_CUI:C0011849
				diabetic retinopathy IDs diabetic retinopathy DOID:8947 ICD9CM:362.0 MESH:D003930 NCI:C34538 UMLS_CUI:C0011884
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754
				type 1 diabetes mellitus IDs type 1 diabetes mellitus DOID:9744 ICD10CM:E10 KEGG:04940 MESH:D003922 NCI:C2986 OMIM:222100 UMLS_CUI:C0011854
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

4
Gene trapped

1
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show an increased mean serum IL-6 response to LPS challenge. Male homozygotes are smaller than controls whereas female homozygotes show an increased mean skin fibroblast proliferation rate. Males homozygous for a different null allele show decreased response of heart to induced stress.

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All GO Annotations

18
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1020
Tissues

141
cDNA Data

21
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acp1

ZFIN acp1

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All Sequences

68
RefSeq

5
UniProt

4
CCDS

CCDS36427.1, CCDS49045.1

Ensembl

ENSMUSG00000044573 (Evidence)
NCBI Gene

11431

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044573	Ensembl Gene Model \| MGI Sequence Detail	18264	C57BL/6J	± kb
transcript	ENSMUST00000062740	Ensembl \| MGI Sequence Detail	3066	Not Applicable
polypeptide	ENSMUSP00000106509	Ensembl \| MGI Sequence Detail	158	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003646 low molecular weight phosphotyrosine protein phosphatase

(term hierarchy)
PDB

2P4U, 5JNU
EC

3.1.3.2, 3.1.3.48
InterPro Domains

IPR050438 Low Molecular Weight Phosphotyrosine Protein Phosphatase

IPR023485 Phosphotyrosine protein phosphatase I

IPR036196 Phosphotyrosine protein phosphatase I superfamily

IPR017867 Protein-tyrosine phosphatase, low molecular weight

IPR002115 Protein-tyrosine phosphatase, low molecular weight, mammalian

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All nucleic 22

cDNA 21

Primer pair 1

Microarray probesets 18

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MGD-MRK-1048, MGD-MRK-1050, MGI:1914786, MGI:2144813

Summaries

All 47

Developmental Gene Expression 4

Gene Ontology 13

Phenotypes 10
Earliest

J:5872 Francke U, et al., Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet. 1977;19(2-3):57-84
Latest

J:330782 Jensen-Cody S, et al., Loss of low-molecular-weight protein tyrosine phosphatase shows limited improvement in glucose tolerance but causes mild cardiac hypertrophy in mice. Am J Physiol Endocrinol Metab. 2022 Jun 1;322(6):E517-E527

TSS for Acp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116034	Chr12:30961592-30961614 (-)	-15 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24