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Acp5 Gene Detail
Summary
  • Symbol
    Acp5
  • Name
    acid phosphatase 5, tartrate resistant
  • Synonyms
    TRACP, TRAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:87883
    NCBI Gene: 11433
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:22038023-22047007 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 8.38 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    395 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87883
 protein coding gene Chr9:22038023-22047042 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034479
 protein coding gene Chr9:19416951-19425945 (-)
A/J MGP_AJ_G0034457
 protein coding gene Chr9:19033557-19042480 (-)
AKR/J MGP_AKRJ_G0034383
 protein coding gene Chr9:19399642-19408572 (-)
BALB/cJ MGP_BALBcJ_G0034448
 protein coding gene Chr9:18912881-18921914 (-)
C3H/HeJ MGP_C3HHeJ_G0034160
 protein coding gene Chr9:19713682-19723986 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034969
 protein coding gene Chr9:20192467-20201429 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031899
 protein coding gene Chr9:18131886-18141195 (-)
CAST/EiJ MGP_CASTEiJ_G0033483
 protein coding gene Chr9:19553440-19562281 (-)
CBA/J MGP_CBAJ_G0034133
 protein coding gene Chr9:20975309-20984360 (-)
DBA/2J MGP_DBA2J_G0034291
 protein coding gene Chr9:18995007-19004057 (-)
FVB/NJ MGP_FVBNJ_G0034234
 protein coding gene Chr9:18549484-18559113 (-)
LP/J MGP_LPJ_G0034377
 protein coding gene Chr9:19576849-19585844 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034278
 protein coding gene Chr9:22516381-22525460 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034989
 protein coding gene Chr9:19376387-19385398 (-)
PWK/PhJ MGP_PWKPhJ_G0033188
 protein coding gene Chr9:19003888-19013061 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033022
 protein coding gene Chr9:19401111-19409905 (-)
WSB/EiJ MGP_WSBEiJ_G0033598
 protein coding gene Chr9:19111462-19120491 (-)



Homology
more
  • Human Ortholog
    ACP5, acid phosphatase 5, tartrate resistant
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACP5, acid phosphatase 5, tartrate resistant
  • Synonyms
    HPAP, TRAcP, TRACP5a, TRACP5b, TRAP, TrATPase
  • Links
    NCBI Gene ID: 54
    neXtProt AC: NX_P13686
    UniProt: P13686

  • Chr Location
    19p13.2; chr19:11574653-11579993 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ACP5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in skeletal defects such as osteopetrosis, and shortening and widening of the bones. Heterozygous mutants display the same phenotype with lesser severity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    962
  • Tissues
    142
  • cDNA Data
    89
  • Literature Summary
    52
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001348 Ensembl Gene Model | MGI Sequence Detail 8985 C57BL/6J ±  kb
    transcript ENSMUST00000069330 Ensembl | MGI Sequence Detail 1356 Not Applicable  
    polypeptide ENSMUSP00000065425 Ensembl | MGI Sequence Detail 327 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 104
      Genomic 5
      cDNA 91
      Primer pair 5
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1052
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 52
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:4082 Grimes R, et al., Assignment of the mouse tartrate-resistant acid phosphatase gene (Acp5) to chromosome 9. Genomics. 1993 Feb;15(2):421-2
    • Latest
      J:341496 Veniaminova NA, et al., Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury. Cell Rep. 2023 Sep 26;42(9):113121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory