Acr MGI Mouse Gene Detail - MGI:87884

Symbol

Acr
Name

acrosin prepropeptide
Synonyms

preproacrosin

Feature Type

protein coding gene
IDs

MGI:87884
NCBI Gene: 11434
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:89452549-89458790 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 44.96 cM, cytoband E-F
Mapping Data

4 experiments

SNPs within 2kb

301 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87884	protein coding gene	Chr15:89452529-89458790 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022240	protein coding gene	Chr15:90779342-90785588 (+)
A/J	MGP_AJ_G0022199	protein coding gene	Chr15:87302919-87309174 (+)
AKR/J	MGP_AKRJ_G0022174	protein coding gene	Chr15:89891626-89897868 (+)
BALB/cJ	MGP_BALBcJ_G0022205	protein coding gene	Chr15:87409793-87416037 (+)
C3H/HeJ	MGP_C3HHeJ_G0021975	protein coding gene	Chr15:89891493-89897752 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022650	protein coding gene	Chr15:94082976-94089235 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020175	protein coding gene	Chr15:83520982-83527146 (+)
CAST/EiJ	MGP_CASTEiJ_G0021497	protein coding gene	Chr15:90672192-90678299 (+)
CBA/J	MGP_CBAJ_G0021942	protein coding gene	Chr15:97268422-97274677 (+)
DBA/2J	MGP_DBA2J_G0022069	protein coding gene	Chr15:86751372-86757618 (+)
FVB/NJ	MGP_FVBNJ_G0022048	protein coding gene	Chr15:85823837-85830079 (+)
LP/J	MGP_LPJ_G0022140	protein coding gene	Chr15:90945281-90951527 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022068	protein coding gene	Chr15:101654376-101660635 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022665	protein coding gene	Chr15:89926888-89933130 (+)
PWK/PhJ	MGP_PWKPhJ_G0021238	protein coding gene	Chr15:86815169-86821575 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021072	protein coding gene	Chr15:89683141-89689382 (+)
WSB/EiJ	MGP_WSBEiJ_G0021546	protein coding gene	Chr15:90430622-90436868 (+)

Human Ortholog

ACR, acrosin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACR, acrosin
Synonyms

SPGF87
Links

HGNC:126

NCBI Gene ID: 49

neXtProt AC: NX_P10323

UniProt: P10323
Chr Location

22q13.33; chr22:50738196-50745339 (+) GRCh38

MGI Vertebrate Homology

Acr stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACR
Protein SuperFamily

Acrosin
Gene Tree

Acr

Diseases

1 with human ACR associations

				Human Disease	Mouse Models
				spermatogenic failure 87 IDs spermatogenic failure 87 DOID:0070586 OMIM:620500

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

1 phenotype from 2 alleles in 2 genetic backgrounds
22 phenotypes from multigenic genotypes
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

2
Targeted

4
Transgenic

7
Genomic Mutations

3 involving Acr
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available

Males homozygous for a targeted null mutation produce sperm that shows delayed fertilization in vitro. Sperm from mutant gonial cells are ineffective at fertilization in competition with normal sperm both in vitro and in vivo.

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All GO Annotations

41
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

1
cDNA Data

18
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

60
RefSeq

14
UniProt

7
CCDS

CCDS27755.1

Ensembl

ENSMUSG00000022622 (Evidence)
NCBI Gene

11434

			Length	Strain/Species	Flank
genomic	11434	NCBI Gene Model \| MGI Sequence Detail	6242	C57BL/6J	± kb
transcript	NM_001277245	RefSeq \| MGI Sequence Detail	1549	ZRU/MplStud
polypeptide	P23578	UniProt \| EBI \| MGI Sequence Detail	436	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000003652 acrosin

(term hierarchy)
EC

3.4.21.10
InterPro Domains

IPR012267 Peptidase S1A, acrosin

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

IPR033116 Serine proteases, trypsin family, serine active site
GlyGen

P23578 2 sites

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All nucleic 25

Genomic 4

cDNA 18

Primer pair 1

Other 2

Microarray probesets 4

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MGD-MRK-1053, MGI:2145978

Summaries

All 94

Developmental Gene Expression 9

Diseases 1

Gene Ontology 13

Phenotypes 42
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Acr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132697	Chr15:89452525-89452528 (+)	-22 bp
Tssr132698	Chr15:89452530-89452586 (+)	9 bp
Tssr132699	Chr15:89458108-89458118 (+)	5,564 bp
Tssr132700	Chr15:89458390-89458405 (+)	5,849 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24