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Chrnd Gene Detail
Summary
  • Symbol
    Chrnd
  • Name
    cholinergic receptor, nicotinic, delta polypeptide
  • Synonyms
    Achr-4, Acrd
  • Feature Type
    protein coding gene
  • IDs
    MGI:87893
    NCBI Gene: 11447
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87118329-87127792 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.07 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    291 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87893
 protein coding gene Chr1:87118319-87127792 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016259
 protein coding gene Chr1:88526567-88537519 (+)
A/J MGP_AJ_G0016240
 protein coding gene Chr1:85218872-85229174 (+)
AKR/J MGP_AKRJ_G0016201
 protein coding gene Chr1:87735119-87746013 (+)
BALB/cJ MGP_BALBcJ_G0016197
 protein coding gene Chr1:85338335-85351416 (+)
C3H/HeJ MGP_C3HHeJ_G0016025
 protein coding gene Chr1:87994819-88005515 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016653
 protein coding gene Chr1:91866535-91875815 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014375
 protein coding gene Chr1:79668993-79678411 (+)
CAST/EiJ MGP_CASTEiJ_G0015610
 protein coding gene Chr1:87198276-87208810 (+)
CBA/J MGP_CBAJ_G0016001
 protein coding gene Chr1:94735578-94745815 (+)
DBA/2J MGP_DBA2J_G0016104
 protein coding gene Chr1:84522290-84535041 (+)
FVB/NJ MGP_FVBNJ_G0016103
 protein coding gene Chr1:83582762-83593836 (+)
LP/J MGP_LPJ_G0016175
 protein coding gene Chr1:89591335-89600639 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016129
 protein coding gene Chr1:98025616-98037776 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016696
 protein coding gene Chr1:87834713-87846940 (+)
PWK/PhJ MGP_PWKPhJ_G0015397
 protein coding gene Chr1:83818927-83830521 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015177
 protein coding gene Chr1:86759606-86770578 (+)
WSB/EiJ MGP_WSBEiJ_G0015674
 protein coding gene Chr1:87503720-87518658 (+)



Homology
more
  • Human Ortholog
    CHRND, cholinergic receptor nicotinic delta subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHRND, cholinergic receptor nicotinic delta subunit
  • Synonyms
    ACHRD, CMS2A, CMS3A, CMS3B, CMS3C, FCCMS, SCCMS
  • Links
    NCBI Gene ID: 1144
    neXtProt AC: NX_Q07001
    UniProt: Q07001

  • Chr Location
    2q37.1; chr2:232525993-232536667 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Chrnd mouse models; 3 with human CHRND associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    23
  • cDNA Data
    13
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026251 Ensembl Gene Model | MGI Sequence Detail 9464 C57BL/6J ±  kb
    transcript ENSMUST00000073252 Ensembl | MGI Sequence Detail 2925 Not Applicable  
    polypeptide ENSMUSP00000072983 Ensembl | MGI Sequence Detail 520 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000005466 acetylcholine receptor subunit delta
      (term hierarchy)
    • InterPro Domains
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
      IPR002394 Nicotinic acetylcholine receptor
    • GlyGen
      P02716 3 sites
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 7
      cDNA 16
      Primer pair 3
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1039, MGD-MRK-1068, MGI:2138724
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 21
      Diseases 1
      Gene Ontology 13
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:353626 Ohkawara B, et al., Transcriptome profile of subsynaptic myonuclei at the neuromuscular junction in embryogenesis. J Neurochem. 2024 Apr;168(4):342-354
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory