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Add1 Gene Detail
Summary
  • Symbol
    Add1
  • Name
    adducin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:87918
    NCBI Gene: 11518
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:34731008-34789652 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.90 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1458 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87918
 protein coding gene Chr5:34731008-34789652 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029467
 protein coding gene Chr5:32819708-32879354 (+)
A/J MGP_AJ_G0029434
 protein coding gene Chr5:31732863-31793835 (+)
AKR/J MGP_AKRJ_G0029383
 protein coding gene Chr5:32958009-33020197 (+)
BALB/cJ MGP_BALBcJ_G0029444
 protein coding gene Chr5:32267716-32327183 (+)
C3H/HeJ MGP_C3HHeJ_G0029166
 protein coding gene Chr5:32994075-33054159 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029898
 protein coding gene Chr5:34707137-34768331 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027135
 protein coding gene Chr5:29512122-29573825 (+)
CAST/EiJ MGP_CASTEiJ_G0028575
 protein coding gene Chr5:32057334-32118686 (+)
CBA/J MGP_CBAJ_G0029134
 protein coding gene Chr5:35490329-35557084 (+)
DBA/2J MGP_DBA2J_G0029282
 protein coding gene Chr5:31902965-31962952 (+)
FVB/NJ MGP_FVBNJ_G0029241
 protein coding gene Chr5:31344315-31403371 (+)
LP/J MGP_LPJ_G0029367
 protein coding gene Chr5:33235145-33298031 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029271
 protein coding gene Chr5:36339754-36402805 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029931
 protein coding gene Chr5:32464682-32526714 (+)
PWK/PhJ MGP_PWKPhJ_G0028300
 protein coding gene Chr5:31046463-31108754 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028131
 protein coding gene Chr5:31900695-31958951 (+)
WSB/EiJ MGP_WSBEiJ_G0028656
 protein coding gene Chr5:32544730-32605652 (+)



Homology
more
  • Human Ortholog
    ADD1, adducin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADD1, adducin 1
  • Synonyms
    ADDA
  • Links
    NCBI Gene ID: 118
    neXtProt AC: NX_P35611
    UniProt: P35611

  • Chr Location
    4p16.3; chr4:2843844-2930076 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Add1 mouse models; 7 with human ADD1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted gene deletion leads to reduced growth and compensated hemolytic anemia. RBCs are osmotically fragile, dehydrated, and spherocytic with severe loss of membrane surface area and reduced MCV. ~50% of homozygotes develop lethal hydrocephaly with dilation of the lateral, 3rd, and 4th ventricles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    741
  • Tissues
    12
  • cDNA Data
    315
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11518 NCBI Gene Model | MGI Sequence Detail 58645 C57BL/6J ±  kb
    transcript NM_001420955 RefSeq | MGI Sequence Detail 4251 ZRU/MplStud  
    polypeptide Q9QYC0 UniProt | EBI | MGI Sequence Detail 735 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 323
      cDNA 316
      Primer pair 5
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1108, MGI:2140823
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 10
      Phenotypes 35
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:317350 O'Neil SD, et al., Action potential-coupled Rho GTPase signaling drives presynaptic plasticity. Elife. 2021 Jul 16;10:e63756
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory