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Plin2 Gene Detail
Summary
  • Symbol
    Plin2
  • Name
    perilipin 2
  • Synonyms
    Adfp, adipophilin, ADPH, Adrp
  • Feature Type
    protein coding gene
  • IDs
    MGI:87920
    NCBI Gene: 11520
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:86566623-86588297 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 40.69 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    717 from dbSNP Build 142
  • Strain Annotations
    16
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87920
 protein coding gene Chr4:86545147-86588518 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028413
 protein coding gene Chr4:86412959-86442505 (-)
A/J MGP_AJ_G0028374
 protein coding gene Chr4:83429955-83448635 (-)
AKR/J MGP_AKRJ_G0028323
 protein coding gene Chr4:85502359-85528784 (-)
BALB/cJ MGP_BALBcJ_G0028394
 protein coding gene Chr4:83603210-83644203 (-)
C3H/HeJ MGP_C3HHeJ_G0028109
 protein coding gene Chr4:86158909-86202976 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028833
 protein coding gene Chr4:89706208-89739966 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026133
 protein coding gene Chr4:79479521-79519928 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0028078
 protein coding gene Chr4:92489110-92521575 (-)
DBA/2J MGP_DBA2J_G0028227
 protein coding gene Chr4:83135468-83199070 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0028327
 protein coding gene Chr4:86749696-86776816 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028222
 protein coding gene Chr4:97536288-97571837 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028870
 protein coding gene Chr4:85577353-85604620 (-)
PWK/PhJ MGP_PWKPhJ_G0027273
 protein coding gene Chr4:81465975-81520859 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027098
 protein coding gene Chr4:83116478-83156575 (-)
WSB/EiJ MGP_WSBEiJ_G0027626
 protein coding gene Chr4:85775435-85800030 (-)



Homology
more
  • Human Ortholog
    PLIN2, perilipin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLIN2, perilipin 2
  • Synonyms
    ADFP, ADRP
  • Links
    NCBI Gene ID: 123
    neXtProt AC: NX_Q99541
    UniProt: Q99541

  • Chr Location
    9p22.1; chr9:19108375-19149290 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations are resistant to diet-induced obesity and hepatic steatosis and may exhibit altered milk composition, vision abnormalities, or small sebaceous glands. Male mice homozygous for a gene trap allele are infertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    8
  • cDNA Data
    368
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028494 Ensembl Gene Model | MGI Sequence Detail 21675 C57BL/6J ±  kb
    transcript ENSMUST00000000466 Ensembl | MGI Sequence Detail 1888 Not Applicable  
    polypeptide ENSMUSP00000000466 Ensembl | MGI Sequence Detail 425 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 381
      Genomic 11
      cDNA 368
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1110, MGD-MRK-1154, MGI:2140117
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 30
      Gene Ontology 12
      Phenotypes 38
    • Earliest
      J:2265 Jiang HP, et al., Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7856-60
    • Latest
      J:355016 Wang Y, et al., Therapeutic siRNA targeting PLIN2 ameliorates steatosis, inflammation, and fibrosis in steatotic liver disease models. J Lipid Res. 2024 Aug 24;65(10):100635
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory