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Adh5 Gene Detail
Summary
  • Symbol
    Adh5
  • Name
    alcohol dehydrogenase 5 (class III), chi polypeptide
  • Synonyms
    Adh3, Adh-5, GSNOR, S-nitrosoglutathione reductase
  • Feature Type
    protein coding gene
  • IDs
    MGI:87929
    NCBI Gene: 11532
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:138148854-138161260 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 64.26 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    564 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87929
 protein coding gene Chr3:138142961-138161260 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027931
 protein coding gene Chr3:141494134-141506472 (+)
A/J MGP_AJ_G0027888
 protein coding gene Chr3:136482579-136495255 (+)
AKR/J MGP_AKRJ_G0027854
 protein coding gene Chr3:140106534-140118692 (+)
BALB/cJ MGP_BALBcJ_G0027900
 protein coding gene Chr3:136294494-136307068 (+)
C3H/HeJ MGP_C3HHeJ_G0027630
 protein coding gene Chr3:140449292-140461569 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028344
 protein coding gene Chr3:146381349-146393692 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025682
 protein coding gene Chr3:131899483-131904291 (+)
CAST/EiJ MGP_CASTEiJ_G0027086
 protein coding gene Chr3:140220520-140233733 (+)
CBA/J MGP_CBAJ_G0027607
 protein coding gene Chr3:151357787-151370125 (+)
DBA/2J MGP_DBA2J_G0027746
 protein coding gene Chr3:135609574-135621849 (+)
FVB/NJ MGP_FVBNJ_G0027713
 protein coding gene Chr3:133066437-133081465 (+)
LP/J MGP_LPJ_G0027856
 protein coding gene Chr3:142883862-142901014 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027745
 protein coding gene Chr3:159465421-159477574 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028402
 protein coding gene Chr3:139660400-139672736 (+)
PWK/PhJ MGP_PWKPhJ_G0026810
 protein coding gene Chr3:135374095-135388291 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026637
 protein coding gene Chr3:137777214-137789189 (+)
WSB/EiJ MGP_WSBEiJ_G0027165
 protein coding gene Chr3:140510258-140522533 (+)



Homology
more
  • Human Ortholog
    ADH5, alcohol dehydrogenase 5 (class III), chi polypeptide
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADH5, alcohol dehydrogenase 5 (class III), chi polypeptide
  • Synonyms
    ADH-3, ADHX, AMEDS, BMFS7, FALDH, FDH, GSH-FDH, GSNOR, HEL-S-60p
  • Links
    NCBI Gene ID: 128
    neXtProt AC: NX_P11766
    UniProt: P11766

  • Chr Location
    4q23; chr4:99070978-99088801 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ADH5 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 4 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are viable with increased S-nitrosothiols in RBCs, increased susceptibility to various toxins, and abnormal blood pressure regulation under anesthesia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    860
  • Tissues
    135
  • cDNA Data
    172
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028138 Ensembl Gene Model | MGI Sequence Detail 12407 C57BL/6J ±  kb
    transcript ENSMUST00000005964 Ensembl | MGI Sequence Detail 1604 Not Applicable  
    polypeptide ENSMUSP00000005964 Ensembl | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 183
      Genomic 3
      cDNA 175
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1119, MGD-MRK-1128
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 11
      Phenotypes 59
    • Earliest
      J:7858 Algar EM, et al., Mouse mitochondrial aldehyde dehydrogenase isozymes: purification and molecular properties. Int J Biochem. 1985;17(1):51-60
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory