Grk2 MGI Mouse Gene Detail - MGI:87940 - G protein-coupled receptor kinase 2

Symbol

Grk2
Name

G protein-coupled receptor kinase 2
Synonyms

Adrbk-1, Adrbk1, Bark-1, beta-adrenergic receptor kinase-1, beta ARK, beta ARK1, betaARK1, beta-AR kinase-1

Feature Type

protein coding gene
IDs

MGI:87940
NCBI Gene: 110355
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr19:4336029-4356250 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 3.98 cM
Mapping Data

8 experiments

SNPs within 2kb

411 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87940	protein coding gene	Chr19:4336029-4356356 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024661	protein coding gene	Chr19:1140948-1166630 (-)
A/J	MGP_AJ_G0024627	protein coding gene	Chr19:1089684-1110806 (-)
AKR/J	MGP_AKRJ_G0024600	protein coding gene	Chr19:1118532-1138693 (-)
BALB/cJ	MGP_BALBcJ_G0024627	protein coding gene	Chr19:1079208-1100401 (-)
C3H/HeJ	MGP_C3HHeJ_G0024395	protein coding gene	Chr19:1117414-1139367 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025075	protein coding gene	Chr19:1184391-1208657 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022504	protein coding gene	Chr19:1027912-1048067 (-)
CAST/EiJ	MGP_CASTEiJ_G0023867	protein coding gene	Chr19:1128186-1148233 (-)
CBA/J	MGP_CBAJ_G0024366	protein coding gene	Chr19:1244633-1268130 (-)
DBA/2J	MGP_DBA2J_G0024494	protein coding gene	Chr19:1050481-1070730 (-)
FVB/NJ	MGP_FVBNJ_G0024461	protein coding gene	Chr19:1060172-1083832 (-)
LP/J	MGP_LPJ_G0024580	protein coding gene	Chr19:1144255-1169170 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024491	protein coding gene	Chr19:1181830-1205245 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025122	protein coding gene	Chr19:1117508-1142141 (-)
PWK/PhJ	MGP_PWKPhJ_G0023613	protein coding gene	Chr19:1104804-1125639 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023418	protein coding gene	Chr19:1100527-1120480 (-)
WSB/EiJ	MGP_WSBEiJ_G0023929	protein coding gene	Chr19:1111786-1134013 (-)

Human Ortholog

GRK2, G protein-coupled receptor kinase 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRK2, G protein-coupled receptor kinase 2
Synonyms

ADRBK1, BARK1, BETA-ARK1
Links

HGNC:289

NCBI Gene ID: 156

neXtProt AC: NX_P25098

UniProt: P25098
Chr Location

11q13.2; chr11:67266473-67286556 (+) GRCh38

MGI Vertebrate Homology

Grk2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GRK2
Gene Tree

Grk2

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Phenotype Summary

39 phenotypes from 3 alleles in 6 genetic backgrounds
1 images
64 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

2
Gene trapped

10
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in embryonic lethality likely due to heart failure. Homozygous mutant embryos are pale in appearance and exhibit ventricular hypoplasia.

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All GO Annotations

92
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

823
Tissues

73
cDNA Data

125
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

65
RefSeq

6
UniProt

8
CCDS

CCDS29426.1, CCDS70915.1

Ensembl

ENSMUSG00000024858 (Evidence)
NCBI Gene

110355

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024858	Ensembl Gene Model \| MGI Sequence Detail	20222	C57BL/6J	± kb
transcript	ENSMUST00000088737	Ensembl \| MGI Sequence Detail	3376	Not Applicable
polypeptide	ENSMUSP00000086114	Ensembl \| MGI Sequence Detail	689	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000003791 beta-adrenergic receptor kinase 1

(term hierarchy)
EC

2.7.11.-, 2.7.11.15
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR000239 GPCR kinase

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR044926 RGS, subdomain 2

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 131

Genomic 2

cDNA 127

Primer pair 1

Other 1

Microarray probesets 5

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MGD-MRK-1149, MGD-MRK-1151, MGD-MRK-1496

Summaries

All 160

Developmental Gene Expression 6

Gene Ontology 16

Phenotypes 64
Earliest

J:33326 Benovic JL, et al., Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A. 1986 May;83(9):2797-801
Latest

J:353362 Walker MF, et al., GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade. PLoS Biol. 2024 Aug;22(8):e3002685

TSS for Grk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157481	Chr19:4356243-4356397 (-)	-70 bp
Tssr157480	Chr19:4356038-4356072 (-)	195 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24