Ads3 QTL Detail

Summary

• Symbol
  Ads3
• Name
  anti dsDNA antibody 3
• Synonyms
  Ads-3

• Feature Type
  QTL
• IDs
  MGI:87945
  NCBI Gene: 109860

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 2 alleles in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

One of four loci controlling dsDNA level in NZB and NZW strains. Ads1 and Ads2 alleles in NZB are dominant and contribute to high levels of IgM with anti-dsDNA specificity; recessive NZW alleles produce little anti-dsDNA antibody.

Sequences &
Gene Models

• NCBI Gene
  109860

Other
Accession IDs

MGD-MRK-1157, MGD-MRK-1161

References

• Summaries
  All 4

  Phenotypes 2
• Earliest
  J:7111 Hirose S, et al., Enhancing effect of H-2-linked NZW gene(s) on the autoimmune traits of (NZB X NZW)F1 mice. J Exp Med. 1983 Jul 1;158(1):228-33
• Latest
  J:7239 Kohno A, et al., Genetic regulation of the class conversion of dsDNA-specific antibodies in (NZB X NZW)F1 hybrid. Immunogenetics. 1983;18(5):513-24