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Adss2 Gene Detail
Summary
  • Symbol
    Adss2
  • Name
    adenylosuccinate synthase 2
  • Synonyms
    Adss, AS
  • Feature Type
    protein coding gene
  • IDs
    MGI:87948
    NCBI Gene: 11566
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:177590742-177624064 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 82.81 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    677 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87948
 protein coding gene Chr1:177590528-177624077 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016850
 protein coding gene Chr1:183965513-184000762 (-)
A/J MGP_AJ_G0016829
 protein coding gene Chr1:176530389-176571451 (-)
AKR/J MGP_AKRJ_G0016795
 protein coding gene Chr1:181822228-181858039 (-)
BALB/cJ MGP_BALBcJ_G0016786
 protein coding gene Chr1:177071859-177106026 (-)
C3H/HeJ MGP_C3HHeJ_G0016612
 protein coding gene Chr1:182425335-182462519 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017251
 protein coding gene Chr1:189958024-189991514 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014957
 protein coding gene Chr1:167810041-167844253 (-)
CAST/EiJ MGP_CASTEiJ_G0016193
 protein coding gene Chr1:181818592-181852993 (-)
CBA/J MGP_CBAJ_G0016585
 protein coding gene Chr1:196899769-196938696 (-)
DBA/2J MGP_DBA2J_G0016691
 protein coding gene Chr1:175400675-175435414 (-)
FVB/NJ MGP_FVBNJ_G0016688
 protein coding gene Chr1:173487057-173520779 (-)
LP/J MGP_LPJ_G0016766
 protein coding gene Chr1:185152425-185187358 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016719
 protein coding gene Chr1:204144759-204179829 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017287
 protein coding gene Chr1:181558743-181593098 (-)
PWK/PhJ MGP_PWKPhJ_G0015980
 protein coding gene Chr1:174487520-174521329 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015757
 protein coding gene Chr1:180664436-180697793 (-)
WSB/EiJ MGP_WSBEiJ_G0016255
 protein coding gene Chr1:181767666-181803217 (-)



Homology
more
  • Human Ortholog
    ADSS2, adenylosuccinate synthase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADSS2, adenylosuccinate synthase 2
  • Synonyms
    ADEH, ADSS, ADSS 2
  • Links
    NCBI Gene ID: 159
    neXtProt AC: NX_P30520
    UniProt: P30520

  • Chr Location
    1q44; chr1:244408494-244452060 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    98
  • cDNA Data
    144
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11566 NCBI Gene Model | MGI Sequence Detail 33323 C57BL/6J ±  kb
    transcript NM_007422 RefSeq | MGI Sequence Detail 2544 C57BL/6  
    polypeptide P46664 UniProt | EBI | MGI Sequence Detail 456 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000003795 adenylosuccinate synthetase isozyme 2
      (term hierarchy)
    • EC
      6.3.4.4
    • InterPro Domains
      IPR033128 Adenylosuccinate synthase, active site
      IPR018220 Adenylosuccinate synthase, GTP-binding site
      IPR001114 Adenylosuccinate synthetase
      IPR042109 Adenylosuccinate synthetase, domain 1
      IPR042110 Adenylosuccinate synthetase, domain 2
      IPR042111 Adenylosuccinate synthetase, domain 3
      IPR027529 Adenylosuccinate synthetase isozyme 2, chordates
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      P46664 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 146
      Genomic 1
      cDNA 145

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1165, MGI:2138197, MGI:7482285
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 3
      Gene Ontology 13
      Phenotypes 18
    • Earliest
      J:306719 Swain JL, et al., Disruption of the purine nucleotide cycle by inhibition of adenylosuccinate lyase produces skeletal muscle dysfunction. J Clin Invest. 1984 Oct;74(4):1422-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory