Aem1 QTL Detail

Summary

• Symbol
  Aem1
• Name
  antierythrocyte autoantibody modifier 1
• Synonyms
  Aem-1

• Feature Type
  QTL
• IDs
  MGI:87950
  NCBI Gene: 107710

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 4, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  3 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 2 alleles in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

This locus modifies the incidence of anti-erythrocyte autoantibodies (AEA) in crosses between NZB and C57BL/6 strains. The recessive allele in NZB allows 100% incidence of AEA and the dominant allele in C57BL/6 prevents production of AEA.

Sequences &
Gene Models

• NCBI Gene
  107710

Other
Accession IDs

MGD-MRK-1171, MGD-MRK-1172

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:7191 Ozaki S, et al., Genetic regulation of erythrocyte autoantibody production in New Zealand black mice. Immunogenetics. 1983;18(3):241-54