Agp3 QTL Detail

Summary

• Symbol
  Agp3
• Name
  anti gp70 immune complex 3
• Synonyms
  Agp-3

• Feature Type
  QTL
• IDs
  MGI:87960
  NCBI Gene: 110038

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

This locus, with Agp1, controls the formation of retroviral gp70-anti-gp70 immune complexes. Low levels of this complex are seen in NZB and NZW; but high levels in the F1s. NZB carries a dominant allele for complex formation at Agp1; NZW carries a dominant allele for enhanced complex level at Agp3.

Sequences &
Gene Models

• NCBI Gene
  110038

Other
Accession IDs

MGD-MRK-1186, MGD-MRK-1189

References

• Summaries
  All 4
• Earliest
  J:7111 Hirose S, et al., Enhancing effect of H-2-linked NZW gene(s) on the autoimmune traits of (NZB X NZW)F1 mice. J Exp Med. 1983 Jul 1;158(1):228-33
• Latest
  J:7239 Kohno A, et al., Genetic regulation of the class conversion of dsDNA-specific antibodies in (NZB X NZW)F1 hybrid. Immunogenetics. 1983;18(5):513-24