Aia1 QTL Detail

Summary

• Symbol
  Aia1
• Name
  autoimmune hemolytic anemia 1
• Synonyms
  Aia-1

• Feature Type
  QTL
• IDs
  MGI:87973
  NCBI Gene: 110113

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 4, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 2 alleles in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Aia1 and Aia2 are postulated to explain the occurrence of autoimmune hemolytic anemia in the NZB strain. The dominant allele of Aia1 determines occurrence of anemia in the NZB strain; the recessive allele determines absence of anemia in the NZC strain and probably most other strains.

Sequences &
Gene Models

• NCBI Gene
  110113

Other
Accession IDs

MGD-MRK-1233, MGD-MRK-1235

References

• Summaries
  All 3

  Phenotypes 1
• Earliest
  J:6517 Knight JG, et al., Genes determining autoimmune disease in New Zealand mice. J Clin Lab Immunol. 1981 May;5(3):165-70