Ak4 MGI Mouse Gene Detail - MGI:87979

Symbol

Ak4
Name

adenylate kinase 4
Synonyms

Ak-3, Ak3l1, Ak-4, D4Ertd274e

Feature Type

protein coding gene
IDs

MGI:87979
NCBI Gene: 11639
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:101276474-101324192 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 46.84 cM
Mapping Data

6 experiments

SNPs within 2kb

1530 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87979	protein coding gene	Chr4:101273675-101324968 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028492	protein coding gene	Chr4:101724083-101780932 (+)
A/J	MGP_AJ_G0028455	protein coding gene	Chr4:98166418-98214705 (+)
AKR/J	MGP_AKRJ_G0028402	protein coding gene	Chr4:100542223-100590306 (+)
BALB/cJ	MGP_BALBcJ_G0028473	protein coding gene	Chr4:98368435-98434130 (+)
C3H/HeJ	MGP_C3HHeJ_G0028186	protein coding gene	Chr4:101335272-101389661 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028912	protein coding gene	Chr4:105568530-105622706 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026204	protein coding gene	Chr4:93422458-93486587 (+)
CAST/EiJ	MGP_CASTEiJ_G0027626	protein coding gene	Chr4:99124420-99176333 (+)
CBA/J	MGP_CBAJ_G0028155	protein coding gene	Chr4:108885400-108942552 (+)
DBA/2J	MGP_DBA2J_G0028305	protein coding gene	Chr4:97861653-97913468 (+)
FVB/NJ	MGP_FVBNJ_G0028272	protein coding gene	Chr4:96701437-96750277 (+)
LP/J	MGP_LPJ_G0028405	protein coding gene	Chr4:102022124-102084969 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028300	protein coding gene	Chr4:114432442-114487805 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028950	protein coding gene	Chr4:100791858-100843751 (+)
PWK/PhJ	MGP_PWKPhJ_G0027351	protein coding gene	Chr4:96030251-96081176 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027173	protein coding gene	Chr4:98242552-98299210 (+)
WSB/EiJ	MGP_WSBEiJ_G0027704	protein coding gene	Chr4:100956358-101012327 (+)

Human Ortholog

AK4, adenylate kinase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AK4, adenylate kinase 4
Synonyms

AK3, AK3L1, AK3L2, AK 4
Links

HGNC:363

NCBI Gene ID: 205

neXtProt AC: NX_P27144

UniProt: P27144
Chr Location

1p31.3

MGI Vertebrate Homology

Ak4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AK4
Gene Tree

Ak4

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

4
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Ak4
Incidental Mutations

APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

35
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

882
Tissues

154
cDNA Data

152
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ak4

ZFIN ak4

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All Sequences

70
RefSeq

14
UniProt

6
CCDS

CCDS18394.1

Ensembl

ENSMUSG00000028527 (Evidence)
NCBI Gene

11639

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028527	Ensembl Gene Model \| MGI Sequence Detail	47719	C57BL/6J	± kb
transcript	ENSMUST00000102780	Ensembl \| MGI Sequence Detail	4186	Not Applicable
polypeptide	ENSMUSP00000099841	Ensembl \| MGI Sequence Detail	223	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000029117 adenylate kinase 4, mitochondrial

(term hierarchy)
EC

2.7.4.10, 2.7.4.4, 2.7.4.6
InterPro Domains

IPR028586 Adenylate kinase 3/4, mitochondrial

IPR028585 Adenylate kinase 4, mitochondrial

IPR007862 Adenylate kinase, active site lid domain

IPR036193 Adenylate kinase, active site lid domain superfamily

IPR033690 Adenylate kinase, conserved site

IPR006259 Adenylate kinase subfamily

IPR000850 Adenylate kinase/UMP-CMP kinase

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

Q9WUR9 1 site, 1 O-linked glycan (1 site)

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All nucleic 158

Genomic 1

cDNA 154

Primer pair 3

Microarray probesets 8

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MGD-MRK-1242, MGD-MRK-1243, MGD-MRK-1246, MGD-MRK-1247, MGI:1098752, MGI:87980

Summaries

All 61

Developmental Gene Expression 8

Gene Ontology 11

Phenotypes 14
Earliest

J:7470 Bonhomme F, et al., Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275-303
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ak4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37989	Chr4:101276498-101276529 (+)	40 bp
Tssr37990	Chr4:101276532-101276546 (+)	65 bp
Tssr37991	Chr4:101276556-101276575 (+)	92 bp
Tssr37992	Chr4:101276893-101276929 (+)	437 bp
Tssr37993	Chr4:101277350-101277393 (+)	898 bp
Tssr37994	Chr4:101303994-101304000 (+)	27,523 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24