Aldoa MGI Mouse Gene Detail - MGI:87994 - aldolase A, fructose-bisphosphate

Symbol

Aldoa
Name

aldolase A, fructose-bisphosphate
Synonyms

Aldo-1, Aldo1

Feature Type

protein coding gene
IDs

MGI:87994
NCBI Gene: 11674
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr7:126394406-126399537 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.25 cM, cytoband F4
Mapping Data

2 experiments

SNPs within 2kb

140 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87994	protein coding gene	Chr7:126394406-126399923 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033000	protein coding gene	Chr7:131093581-131099540 (-)
A/J	MGP_AJ_G0032983	protein coding gene	Chr7:127621196-127626715 (-)
AKR/J	MGP_AKRJ_G0032915	protein coding gene	Chr7:130854762-130862106 (-)
BALB/cJ	MGP_BALBcJ_G0032988	protein coding gene	Chr7:127282912-127288427 (-)
C3H/HeJ	MGP_C3HHeJ_G0032698	protein coding gene	Chr7:130792427-130798499 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033494	protein coding gene	Chr7:136187991-136193487 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030466	protein coding gene	Chr7:128813691-128819206 (-)
CAST/EiJ	MGP_CASTEiJ_G0032027	protein coding gene	Chr7:122579353-122584860 (-)
CBA/J	MGP_CBAJ_G0032671	protein coding gene	Chr7:140771418-140779673 (-)
DBA/2J	MGP_DBA2J_G0032823	protein coding gene	Chr7:125594767-125600378 (-)
FVB/NJ	MGP_FVBNJ_G0032776	protein coding gene	Chr7:125443465-125448978 (-)
LP/J	MGP_LPJ_G0032917	protein coding gene	Chr7:132563960-132569463 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032808	protein coding gene	Chr7:141955829-141962534 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033513	protein coding gene	Chr7:129861951-129867498 (-)
PWK/PhJ	MGP_PWKPhJ_G0031734	protein coding gene	Chr7:118589865-118595626 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031580	protein coding gene	Chr7:116711657-116717182 (-)
WSB/EiJ	MGP_WSBEiJ_G0032139	protein coding gene	Chr7:130841480-130846972 (-)

Human Ortholog

ALDOA, aldolase, fructose-bisphosphate A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALDOA, aldolase, fructose-bisphosphate A
Synonyms

ALDA, GSD12, HEL-S-87p
Links

HGNC:414

NCBI Gene ID: 226

neXtProt AC: NX_P04075

UniProt: P04075
Chr Location

16p11.2; chr16:30064164-30070457 (+) GRCh38

MGI Vertebrate Homology

Aldoa stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ALDOA
Gene Tree

Aldoa

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References

3 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
50 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Endonuclease-mediated

2
Gene trapped

23
Targeted

8
Genomic Mutations

5 involving Aldoa
Incidental Mutations

APF
Find Mice (IMSR)

28 strains or lines available

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All GO Annotations

41
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

305
Tissues

203
cDNA Data

1045
Literature Summary

31

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase aldoa

ZFIN aldoab

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All Sequences

82
RefSeq

14
UniProt

1
CCDS

CCDS21845.1, CCDS52399.1

Ensembl

ENSMUSG00000030695 (Evidence)
NCBI Gene

11674

			Length	Strain/Species	Flank
genomic	11674	NCBI Gene Model \| MGI Sequence Detail	5132	C57BL/6J	± kb
transcript	NM_001177307	RefSeq \| MGI Sequence Detail	1595	C57BL/6
polypeptide	P05064	UniProt \| EBI \| MGI Sequence Detail	364	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003934 fructose-bisphosphate aldolase A

(term hierarchy)

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All nucleic 1053

Genomic 2

cDNA 1045

Primer pair 5

Other 1

Microarray probesets 6

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MGD-MRK-1276, MGD-MRK-1278

Summaries

All 127

Developmental Gene Expression 31

Diseases 3

Gene Ontology 16

Phenotypes 50
Earliest

J:21434 Paolella G, et al., Structure and expression of mouse aldolase genes. Brain-specific aldolase C amino acid sequence is closely related to aldolase A. Eur J Biochem. 1986 Apr 15;156(2):229-35
Latest

J:349484 Henis M, et al., The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation. Sci Adv. 2024 Apr 12;10(15):eadf7001

TSS for Aldoa:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr74838	Chr7:126399778-126399827 (-)	-266 bp
Tssr74837	Chr7:126399697-126399702 (-)	-163 bp
Tssr74836	Chr7:126399526-126399602 (-)	-27 bp
Tssr74835	Chr7:126399500-126399509 (-)	32 bp
Tssr2399	Chr7:126399321-126399337 (-)	208 bp
Tssr74834	Chr7:126399209-126399226 (-)	319 bp
Tssr74833	Chr7:126398722-126398760 (-)	796 bp
Tssr74832	Chr7:126398335-126398363 (-)	1,188 bp
Tssr74831	Chr7:126398306-126398327 (-)	1,220 bp
Tssr74830	Chr7:126397958-126397976 (-)	1,570 bp
Tssr74829	Chr7:126397764-126397779 (-)	1,765 bp
Tssr74828	Chr7:126397675-126397690 (-)	1,854 bp
Tssr74827	Chr7:126397418-126397434 (-)	2,111 bp
Tssr74826	Chr7:126397068-126397100 (-)	2,453 bp
Tssr74825	Chr7:126396920-126396966 (-)	2,594 bp
Tssr74824	Chr7:126396651-126396677 (-)	2,873 bp
Tssr74823	Chr7:126396603-126396607 (-)	2,932 bp
Tssr74822	Chr7:126395830-126395843 (-)	3,700 bp
Tssr74821	Chr7:126394873-126394900 (-)	4,650 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24