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Aldob Gene Detail
Summary
  • Symbol
    Aldob
  • Name
    aldolase B, fructose-bisphosphate
  • Synonyms
    Aldo-2, Aldo2
  • Feature Type
    protein coding gene
  • IDs
    MGI:87995
    NCBI Gene: 230163
  • Alliance
    gene page
  • Transcription Start Sites
    29 TSS
  • Candidate for QTL
    5 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:49535995-49549546 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 26.57 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    440 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87995
 protein coding gene Chr4:49535993-49549546 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028284
 protein coding gene Chr4:48018710-48032206 (-)
A/J MGP_AJ_G0028244
 protein coding gene Chr4:46239561-46253113 (-)
AKR/J MGP_AKRJ_G0028193
 protein coding gene Chr4:47456239-47469782 (-)
BALB/cJ MGP_BALBcJ_G0028263
 protein coding gene Chr4:46347560-46363109 (-)
C3H/HeJ MGP_C3HHeJ_G0027984
 protein coding gene Chr4:48011969-48026001 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028704
 protein coding gene Chr4:49747444-49762423 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026013
 protein coding gene Chr4:43445469-43458962 (-)
CAST/EiJ MGP_CASTEiJ_G0027423
 protein coding gene Chr4:47579897-47593418 (-)
CBA/J MGP_CBAJ_G0027950
 protein coding gene Chr4:51449238-51461073 (-)
DBA/2J MGP_DBA2J_G0028100
 protein coding gene Chr4:46124766-46138245 (-)
FVB/NJ MGP_FVBNJ_G0028067
 protein coding gene Chr4:45388199-45402245 (-)
LP/J MGP_LPJ_G0028199
 protein coding gene Chr4:48097611-48109474 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028091
 protein coding gene Chr4:54365333-54378875 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028739
 protein coding gene Chr4:47649642-47663140 (-)
PWK/PhJ MGP_PWKPhJ_G0027148
 protein coding gene Chr4:46200809-46214538 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026976
 protein coding gene Chr4:47038848-47052225 (-)
WSB/EiJ MGP_WSBEiJ_G0027501
 protein coding gene Chr4:47557262-47571844 (-)



Homology
more
  • Human Ortholog
    ALDOB, aldolase, fructose-bisphosphate B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALDOB, aldolase, fructose-bisphosphate B
  • Synonyms
    ALDB, ALDO2
  • Links
    NCBI Gene ID: 229
    neXtProt AC: NX_P05062
    UniProt: P05062

  • Chr Location
    9q31.1; chr9:101420560-101449664 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ALDOB associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Following exposure to a 40% fructose diet, mice homozygous for a null allele exhibit failure to thrive, liver pathology and dysfunction, and a high mortality rate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    930
  • Tissues
    163
  • cDNA Data
    934
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028307 Ensembl Gene Model | MGI Sequence Detail 13552 C57BL/6J ±  kb
    transcript ENSMUST00000029987 Ensembl | MGI Sequence Detail 2016 Not Applicable  
    polypeptide ENSMUSP00000029987 Ensembl | MGI Sequence Detail 364 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 939
      Genomic 2
      cDNA 934
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1277, MGD-MRK-1279, MGI:2387622
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 13
      Gene Ontology 13
      Phenotypes 13
    • Earliest
      J:322154 Hue L, et al., The conversion of (4- 3 H)fructose and of (4- 3 H)glucose to liver glycogen in the mouse. An investigation of the glyceraldehyde crossroads. Eur J Biochem. 1972 Sep 18;29(2):268-75
    • Latest
      J:357543 Buziau AM, et al., Hepatic glucokinase regulatory protein and carbohydrate response element binding protein attenuation reduce de novo lipogenesis but do not mitigate intrahepatic triglyceride accumulation in Aldob deficiency. Mol Metab. 2024 Sep;87:101984
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory