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Alox15 Gene Detail
Summary
  • Symbol
    Alox15
  • Name
    arachidonate 15-lipoxygenase
  • Synonyms
    12-LO, Alox12l, L-12LO
  • Feature Type
    protein coding gene
  • IDs
    MGI:87997
    NCBI Gene: 11687
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70234978-70242857 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.99 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87997
 protein coding gene Chr11:70234973-70279465 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018592
 protein coding gene Chr11:70876161-70884024 (-)
A/J MGP_AJ_G0018560
 protein coding gene Chr11:68179322-68187185 (-)
AKR/J MGP_AKRJ_G0018529
 protein coding gene Chr11:70214639-70222503 (-)
BALB/cJ MGP_BALBcJ_G0018532
 protein coding gene Chr11:68499557-68507420 (-)
C3H/HeJ MGP_C3HHeJ_G0018345
 protein coding gene Chr11:70252130-70259993 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018983
 protein coding gene Chr11:72978499-72986362 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016628
 protein coding gene Chr11:65108543-65116473 (-)
CAST/EiJ MGP_CASTEiJ_G0017900
 protein coding gene Chr11:70502623-70512074 (-)
CBA/J MGP_CBAJ_G0018317
 protein coding gene Chr11:76294111-76301974 (-)
DBA/2J MGP_DBA2J_G0018427
 protein coding gene Chr11:67756200-67764099 (-)
FVB/NJ MGP_FVBNJ_G0018417
 protein coding gene Chr11:67408506-67416706 (-)
LP/J MGP_LPJ_G0018497
 protein coding gene Chr11:71443799-71452006 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018440
 protein coding gene Chr11:76855368-76863565 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019025
 protein coding gene Chr11:70491230-70501962 (-)
PWK/PhJ MGP_PWKPhJ_G0017674
 protein coding gene Chr11:68408556-68416770 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017464
 protein coding gene Chr11:70294792-70302726 (-)
WSB/EiJ MGP_WSBEiJ_G0017954
 protein coding gene Chr11:70153192-70162034 (-)



Homology
more
  • Human Ortholog
    ALOX15, arachidonate 15-lipoxygenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALOX15, arachidonate 15-lipoxygenase
  • Synonyms
    12-LOX, 15-LOX, 15-LOX-1, LOG15
  • Links
    NCBI Gene ID: 246
    neXtProt AC: NX_P16050
    UniProt: P16050

  • Chr Location
    17p13.2; chr17:4630919-4642294 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 5 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    142 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show altered arachidonic acid metabolism and develop a myeloproliferative disorder associated with splenomegaly, abnormal splenic architecture, leukocystosis, basophilia, abnormal lymph node morphology, dermatitis, and premature death likely due to anemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    831
  • Tissues
    109
  • cDNA Data
    16
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018924 Ensembl Gene Model | MGI Sequence Detail 7880 C57BL/6J ±  kb
    transcript ENSMUST00000019068 Ensembl | MGI Sequence Detail 2409 Not Applicable  
    polypeptide ENSMUSP00000019068 Ensembl | MGI Sequence Detail 663 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 16
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1284
    References
    more
    • Summaries
      All 212
      Developmental Gene Expression 8
      Gene Ontology 13
      Phenotypes 142
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:357484 Koenis DS, et al., Efferocyte-Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1-Mediated Activation of Glycolysis. Adv Sci (Weinh). 2024 Feb;11(7):e2304690
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory