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Mat1a Gene Detail
Summary
  • Symbol
    Mat1a
  • Name
    methionine adenosyltransferase 1A
  • Synonyms
    AdoMet, Ams, MAT, MATA1, SAMS, SAMS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88017
    NCBI Gene: 11720
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:40826992-40846369 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 22.36 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    589 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88017
 protein coding gene Chr14:40826969-40846385 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021196
 protein coding gene Chr14:34736968-34755964 (+)
A/J MGP_AJ_G0021144
 protein coding gene Chr14:33389372-33408403 (+)
AKR/J MGP_AKRJ_G0021121
 protein coding gene Chr14:34753721-34772735 (+)
BALB/cJ MGP_BALBcJ_G0021148
 protein coding gene Chr14:33607810-33626841 (+)
C3H/HeJ MGP_C3HHeJ_G0020931
 protein coding gene Chr14:34716369-34735400 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021580
 protein coding gene Chr14:36135027-36154058 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019142
 protein coding gene Chr14:33011380-33028858 (+)
CAST/EiJ MGP_CASTEiJ_G0020456
 protein coding gene Chr14:34486029-34505005 (+)
CBA/J MGP_CBAJ_G0020897
 protein coding gene Chr14:37361572-37380609 (+)
DBA/2J MGP_DBA2J_G0021020
 protein coding gene Chr14:33342449-33367675 (+)
FVB/NJ MGP_FVBNJ_G0021004
 protein coding gene Chr14:33285754-33304732 (+)
LP/J MGP_LPJ_G0021089
 protein coding gene Chr14:34970793-34988201 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021030
 protein coding gene Chr14:36987410-37006826 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021613
 protein coding gene Chr14:34537738-34556757 (+)
PWK/PhJ MGP_PWKPhJ_G0020204
 protein coding gene Chr14:32818280-32837435 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020028
 protein coding gene Chr14:34162719-34180385 (+)
WSB/EiJ MGP_WSBEiJ_G0020511
 protein coding gene Chr14:34655028-34674053 (+)



Homology
more
  • Human Ortholog
    MAT1A, methionine adenosyltransferase 1A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAT1A, methionine adenosyltransferase 1A
  • Synonyms
    MAT, MATA1, SAMS, SAMS1
  • Links
    NCBI Gene ID: 4143
    neXtProt AC: NX_Q00266
    UniProt: Q00266

  • Chr Location
    10q22.3; chr10:80271820-80289658 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MAT1A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    2 images
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have significantly elevated levels of methionine in the circulation and develop liver steatosis with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    120
  • cDNA Data
    13
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037798 Ensembl Gene Model | MGI Sequence Detail 19378 C57BL/6J ±  kb
    transcript ENSMUST00000047286 Ensembl | MGI Sequence Detail 3208 Not Applicable  
    polypeptide ENSMUSP00000044288 Ensembl | MGI Sequence Detail 396 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000010201 S-adenosylmethionine synthetase isoform type-1
      (term hierarchy)
    • EC
      2.5.1.6
    • InterPro Domains
      IPR002133 S-adenosylmethionine synthetase
      IPR022629 S-adenosylmethionine synthetase, central domain
      IPR022631 S-adenosylmethionine synthetase, conserved site
      IPR022630 S-adenosylmethionine synthetase, C-terminal
      IPR022628 S-adenosylmethionine synthetase, N-terminal
      IPR022636 S-adenosylmethionine synthetase superfamily
    • GlyGen
      Q91X83 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 2
      cDNA 13
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1311, MGI:2145596
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 86
    • Earliest
      J:12854 Sakata SF, et al., Cloning and expression of murine S-adenosylmethionine synthetase. J Biol Chem. 1993 Jul 5;268(19):13978-86
    • Latest
      J:351998 Vastagh C, et al., Cholinergic Control of GnRH Neuron Physiology and Luteinizing Hormone Secretion in Male Mice: Involvement of ACh/GABA Cotransmission. J Neurosci. 2024 Mar 20;44(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory