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Amy2a5 Gene Detail
Summary
  • Symbol
    Amy2a5
  • Name
    amylase 2a5
  • Synonyms
    Amy-2, Amy2, mAmy2-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88020
    NCBI Gene: 109959
  • Member of
    Amy cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr3:113156494-113166015 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 49.35 cM
  • Mapping Data
    38 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    4
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88020
 protein coding gene Chr3:113154494-113166153 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027798
 protein coding gene Chr3:115093533-115094378 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0027722
 protein coding gene Chr3:114331977-114351419 (-)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0028213
 protein coding gene Chr3:119231412-119529658 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    AMY1A, amylase alpha 1A
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMY2A, amylase alpha 2A
  • Synonyms
    AMY2, PA
  • Links
    NCBI Gene ID: 279
    neXtProt AC: NX_P04746
    UniProt: P04746

  • Chr Location
    1p21.1; chr1:103616651-103625780 (+)  GRCh38
  • Human Ortholog
    AMY2B, amylase alpha 2B
  • Synonyms
    AMY2, AMY3, HXA
  • Links
    NCBI Gene ID: 280
    neXtProt AC: NX_P19961
    UniProt: P19961

  • Chr Location
    1p21.1; chr1:103553815-103579534 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    2
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Amy2a5
  • Find Mice (IMSR)
    1 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    13
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 109959 NCBI Gene Model | MGI Sequence Detail 9522 C57BL/6J ±  kb
transcript NM_001042711 RefSeq | MGI Sequence Detail 1577 ZRU/MplStud  
polypeptide P00688 UniProt | EBI | MGI Sequence Detail 508 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 20
    Genomic 4
    cDNA 14
    Other 2

    Microarray probesets 8
Other
Accession IDs
less
MGD-MRK-1314, MGD-MRK-1316
References
more
  • Summaries
    All 111
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:12977 Sick K, et al., Genetics of amylase isozymes in the mouse. Hereditas. 1964;51:291-296
  • Latest
    J:337474 Cobo I, et al., NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. Nat Commun. 2023 Jun 23;14(1):3761
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory