anx Gene Detail

Summary

• Symbol
  anx
• Name
  anorexia

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:88029
  NCBI Gene: 11743
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 2, Syntenic
• Mapping Data
  4 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  25 phenotypes from 1 allele in 2 genetic backgrounds
  9 phenotypes from multigenic genotypes
  21 phenotype references
  

• All Mutations and Alleles
  1
• Spontaneous
  1
• Find Mice (IMSR)
  1 strains or lines available

Homozygotes for a spontaneous mutation exhibit reduced growth, head weaving, hyperactivity, low food intake, elevated serotonergic stimulation, altered neuropeptide Y processing in the hypothalamic arcuate nucleus, and periweaning lethality.

Sequences &
Gene Models

• NCBI Gene
  11743

References

• Summaries
  All 24

  Phenotypes 21
• Earliest
  J:28102 Williams CL, et al., Inhibition of suckling in weaning-age rats: a possible serotonergic mechanism. J Comp Physiol Psychol. 1979 Jun;93(3):414-29
• Latest
  J:241666 Kim DY, et al., The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia (anx) mutation. Dis Model Mech. 2017 May 01;10(5):581-595