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Apc Gene Detail
Summary
  • Symbol
    Apc
  • Name
    APC, WNT signaling pathway regulator
  • Synonyms
    adenomatosis polyposis coli, CC1, Min
  • Feature Type
    protein coding gene
  • IDs
    MGI:88039
    NCBI Gene: 11789
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:34353977-34455605 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 18.53 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2419 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88039
 protein coding gene Chr18:34353350-34455605 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024236
 protein coding gene Chr18:32422297-32522776 (+)
A/J MGP_AJ_G0024202
 protein coding gene Chr18:31322330-31427022 (+)
AKR/J MGP_AKRJ_G0024171
 protein coding gene Chr18:32207234-32316309 (+)
BALB/cJ MGP_BALBcJ_G0024202
 protein coding gene Chr18:31382720-31489899 (+)
C3H/HeJ MGP_C3HHeJ_G0023970
 protein coding gene Chr18:32235351-32341715 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024644
 protein coding gene Chr18:33652686-33758150 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022085
 protein coding gene Chr18:31476837-31579520 (+)
CAST/EiJ MGP_CASTEiJ_G0023445
 protein coding gene Chr18:32170740-32277521 (+)
CBA/J MGP_CBAJ_G0023938
 protein coding gene Chr18:34568909-34685897 (+)
DBA/2J MGP_DBA2J_G0024070
 protein coding gene Chr18:30988456-31091204 (+)
FVB/NJ MGP_FVBNJ_G0024036
 protein coding gene Chr18:30677700-30778922 (+)
LP/J MGP_LPJ_G0024151
 protein coding gene Chr18:32501654-32606547 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024064
 protein coding gene Chr18:35879069-35987876 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024692
 protein coding gene Chr18:32044036-32147453 (+)
PWK/PhJ MGP_PWKPhJ_G0023188
 protein coding gene Chr18:31174765-31275552 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022997
 protein coding gene Chr18:32316583-32418980 (+)
WSB/EiJ MGP_WSBEiJ_G0023508
 protein coding gene Chr18:31968185-32072038 (+)



Homology
more
  • Human Ortholog
    APC, APC regulator of WNT signaling pathway
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APC, APC regulator of WNT signaling pathway
  • Synonyms
    BTPS2, DESMD, DP2, DP2.5, DP3, GS, PPP1R46
  • Links
    NCBI Gene ID: 324
    neXtProt AC: NX_P25054
    UniProt: P25054

  • Chr Location
    5q22.2; chr5:112707498-112846239 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with Apc mouse models; 17 with human APC associations

Human Disease Mouse Models
      
IDs
 View 13 models
IDs
 View 1 model
IDs
 View 1 model
      
IDs
 View 2 models
IDs
 View 10 models
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    12 with disease annotations
  • References
    31 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    231 phenotypes from 25 alleles in 56 genetic backgrounds
    157 phenotypes from multigenic genotypes
    23 images
    1607 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most targeted and hypomorphic heterozygous mutants develop intestinal polyps and colorectal cancer, associated with anemia from intestinal bleeding. Homozygotes are embryonic lethal. Homozygotes for a mild alleles survive and have less extreme tumor incidence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    304
  • GO References
    113
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1050
  • Tissues
    160
  • cDNA Data
    228
  • Literature Summary
    119
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005871 Ensembl Gene Model | MGI Sequence Detail 101629 C57BL/6J ±  kb
    transcript ENSMUST00000079362 Ensembl | MGI Sequence Detail 12811 Not Applicable  
    polypeptide ENSMUSP00000078337 Ensembl | MGI Sequence Detail 2842 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 246
      Genomic 1
      cDNA 232
      Primer pair 11
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-1347, MGD-MRK-16245, MGI:2147196, MGI:2147309, MGI:2147352
    References
    more
    • Summaries
      All 1842
      Developmental Gene Expression 119
      Diseases 31
      Gene Ontology 113
      Phenotypes 1607
    • Earliest
      J:103 Lane PW, et al., Mahogany, a recessive color mutation in linkage group V of the mouse. J Hered. 1960;51(5):228-230
    • Latest
      J:358839 Georgieva TG, et al., Kallikrein-Related Peptidase 6 Contributes to Murine Intestinal Tumorigenesis Driven by a Mutant Adenomatous polyposis coli Gene. Cancers (Basel). 2024 Nov 15;16(22)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory