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Aplp1 Gene Detail
Summary
  • Symbol
    Aplp1
  • Name
    amyloid beta precursor like protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88046
    NCBI Gene: 11803
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30134407-30144960 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 18.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    418 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88046
 protein coding gene Chr7:30134405-30144960 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032020
 protein coding gene Chr7:29422928-29438326 (-)
A/J MGP_AJ_G0031997
 protein coding gene Chr7:28638796-28649447 (-)
AKR/J MGP_AKRJ_G0031930
 protein coding gene Chr7:29369262-29380427 (-)
BALB/cJ MGP_BALBcJ_G0032004
 protein coding gene Chr7:28817215-28827869 (-)
C3H/HeJ MGP_C3HHeJ_G0031723
 protein coding gene Chr7:29815485-29826500 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032470
 protein coding gene Chr7:30383476-30394089 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029520
 protein coding gene Chr7:29674384-29684937 (-)
CAST/EiJ MGP_CASTEiJ_G0031057
 protein coding gene Chr7:23074486-23085114 (-)
CBA/J MGP_CBAJ_G0031689
 protein coding gene Chr7:31828761-31840062 (-)
DBA/2J MGP_DBA2J_G0031841
 protein coding gene Chr7:28368722-28379349 (-)
FVB/NJ MGP_FVBNJ_G0031798
 protein coding gene Chr7:28488905-28499853 (-)
LP/J MGP_LPJ_G0031922
 protein coding gene Chr7:29741395-29753222 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031834
 protein coding gene Chr7:31082499-31093153 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032498
 protein coding gene Chr7:28870128-28880789 (-)
PWK/PhJ MGP_PWKPhJ_G0030783
 protein coding gene Chr7:23405700-23417108 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030616
 protein coding gene Chr7:19875244-19885758 (-)
WSB/EiJ MGP_WSBEiJ_G0031167
 protein coding gene Chr7:29254079-29266288 (-)



Homology
more
  • Human Ortholog
    APLP1, amyloid beta precursor like protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APLP1, amyloid beta precursor like protein 1
  • Synonyms
    APLP
  • Links
    NCBI Gene ID: 333
    neXtProt AC: NX_P51693
    UniProt: P51693

  • Chr Location
    19q13.12; chr19:35867899-35879803 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation in this gene show a 10% decrease in body weight at 9 weeks of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    885
  • Tissues
    79
  • cDNA Data
    85
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006651 Ensembl Gene Model | MGI Sequence Detail 10554 C57BL/6J ±  kb
    transcript ENSMUST00000006828 Ensembl | MGI Sequence Detail 2343 Not Applicable  
    polypeptide ENSMUSP00000006828 Ensembl | MGI Sequence Detail 654 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004136 amyloid beta precursor like protein 1
      (term hierarchy)
    • InterPro Domains
      IPR008155 Amyloidogenic glycoprotein
      IPR011178 Amyloidogenic glycoprotein, copper-binding
      IPR019744 Amyloidogenic glycoprotein, copper-binding domain conserved site
      IPR036669 Amyloidogenic glycoprotein, copper-binding domain superfamily
      IPR024329 Amyloidogenic glycoprotein, E2 domain
      IPR008154 Amyloidogenic glycoprotein, extracellular
      IPR015849 Amyloidogenic glycoprotein, heparin-binding
      IPR036454 Amyloidogenic glycoprotein, heparin-binding domain superfamily
      IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved site
      IPR019543 Beta-amyloid precursor protein C-terminal
      IPR036176 E2 domain superfamily
    • GlyGen
      Q03157 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 91
      Genomic 1
      cDNA 87
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1360
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 14
      Gene Ontology 15
      Phenotypes 21
    • Earliest
      J:3302 Wasco W, et al., Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10758-62
    • Latest
      J:349362 Mao X, et al., Aplp1 interacts with Lag3 to facilitate transmission of pathologic alpha-synuclein. Nat Commun. 2024 May 31;15(1):4663
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory