Apoa1 MGI Mouse Gene Detail - MGI:88049

Symbol

Apoa1
Name

apolipoprotein A-I
Synonyms

Alp-1, Apoa-1, Brp-14, Ltw-1, Lvtw-1, Sep-1, Sep-2, Sep2

Feature Type

protein coding gene
IDs

MGI:88049
NCBI Gene: 11806
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr9:46139928-46141767 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 25.36 cM, cytoband A2-A4
Mapping Data

69 experiments

SNPs within 2kb

153 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88049	protein coding gene	Chr9:46139878-46141767 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034748	protein coding gene	Chr9:44858667-44860553 (+)
A/J	MGP_AJ_G0034729	protein coding gene	Chr9:43574365-43576263 (+)
AKR/J	MGP_AKRJ_G0034656	protein coding gene	Chr9:44462543-44464429 (+)
BALB/cJ	MGP_BALBcJ_G0034720	protein coding gene	Chr9:43295876-43297774 (+)
C3H/HeJ	MGP_C3HHeJ_G0034431	protein coding gene	Chr9:44936599-44938497 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035241	protein coding gene	Chr9:46139445-46141331 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032155	protein coding gene	Chr9:43105006-43106903 (+)
CAST/EiJ	MGP_CASTEiJ_G0033753	protein coding gene	Chr9:44794642-44796528 (+)
CBA/J	MGP_CBAJ_G0034403	protein coding gene	Chr9:47824679-47826577 (+)
DBA/2J	MGP_DBA2J_G0034562	protein coding gene	Chr9:43445649-43447547 (+)
FVB/NJ	MGP_FVBNJ_G0034503	protein coding gene	Chr9:42709404-42711302 (+)
LP/J	MGP_LPJ_G0034643	protein coding gene	Chr9:45177188-45179074 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034547	protein coding gene	Chr9:49573347-49575245 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035262	protein coding gene	Chr9:44381663-44383549 (+)
PWK/PhJ	MGP_PWKPhJ_G0033458	protein coding gene	Chr9:43364635-43366521 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033294	protein coding gene	Chr9:44710282-44712143 (+)
WSB/EiJ	MGP_WSBEiJ_G0033866	protein coding gene	Chr9:44430654-44432545 (+)

Human Ortholog

APOA1, apolipoprotein A1

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

APOA1, apolipoprotein A1
Synonyms

AMYLD3, apo(a), HPALP2
Links

HGNC:600

NCBI Gene ID: 335

neXtProt AC: NX_P02647

UniProt: P02647
Chr Location

11q23.3; chr11:116835751-116837950 (-) GRCh38

MGI Vertebrate Homology

Apoa1 stringent orthology
1 human;1 mouse;1 rat;4 zebrafish
HCOP

vertebrate homology predictions: APOA1
Gene Tree

Apoa1

Diseases

8 with human APOA1 associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				atherosclerosis IDs atherosclerosis DOID:1936 EFO:0003914 ICD10CM:I70 ICD9CM:440 MESH:D050197 NCI:C35768 UMLS_CUI:C0004153
				familial hypercholesterolemia IDs familial hypercholesterolemia DOID:13810 ICD10CM:E78.01 MESH:D006938 NCI:C34704 OMIM:143890 ORDO:406 UMLS_CUI:C0020445
				hypolipoproteinemia IDs hypolipoproteinemia DOID:1387 ICD10CM:E78.6 ICD9CM_2006:272.5 ICD9CM:272.5 MESH:D007009 UMLS_CUI:C0020623
				metabolic dysfunction-associated steatohepatitis IDs metabolic dysfunction-associated steatohepatitis DOID:0080547
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				primary hypoalphalipoproteinemia 2 IDs primary hypoalphalipoproteinemia 2 DOID:0080958 OMIM:618463 ORDO:425
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 2 alleles in 5 genetic backgrounds
21 phenotypes from multigenic genotypes
106 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Gene trapped

1
Spontaneous

1
Targeted

6
Genomic Mutations

1 involving Apoa1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit reduced high density lipoprotein (HDL), non-HDL cholesterol, and cholesterol ester levels, increased plasma triglyceride and free cholesterol levels, and impaired corticosteroid synthesis.

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All GO Annotations

160
GO References

38

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

832
Tissues

46
cDNA Data

1027
Literature Summary

36

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase apoa1

ZFIN apoa1a, apoa1b

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All Sequences

45
RefSeq

2
UniProt

4
CCDS

CCDS40610.1

Ensembl

ENSMUSG00000032083 (Evidence)
NCBI Gene

11806

			Length	Strain/Species	Flank
genomic	11806	NCBI Gene Model \| MGI Sequence Detail	1840	C57BL/6J	± kb
transcript	NM_009692	RefSeq \| MGI Sequence Detail	988	ZRU/MplStud
polypeptide	Q00623	UniProt \| EBI \| MGI Sequence Detail	264	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004140 apolipoprotein A-I

(term hierarchy)
PDB

2LEM
InterPro Domains

IPR050163 Apolipoprotein A1/A4/E

IPR000074 Apolipoprotein A/E
GlyGen

Q00623 1 site, 1 O-linked glycan (1 site)

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All nucleic 1046

Genomic 5

cDNA 1028

Primer pair 10

Other 3

Microarray probesets 4

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MGD-MRK-11918, MGD-MRK-11941, MGD-MRK-1288, MGD-MRK-1364, MGD-MRK-1367, MGD-MRK-14361, MGD-MRK-14362, MGD-MRK-14363, MGD-MRK-1639

Summaries

All 316

Developmental Gene Expression 36

Gene Ontology 38

Phenotypes 106
Earliest

J:15312 Scanu A, et al., Fractionation of human serum high density lipoprotein in urea solutions. Evidence for polypeptide heterogeneity. Biochemistry. 1969 Aug;8(8):3309-16
Latest

J:355529 Wang ZY, et al., Apolipoprotein A-1 Accelerated Liver Regeneration Through Regulating Autophagy Via AMPK-ULK1 Pathway. Cell Mol Gastroenterol Hepatol. 2024;17(4):539-551

TSS for Apoa1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84839	Chr9:46139645-46139672 (+)	-269 bp
Tssr84840	Chr9:46139999-46140012 (+)	78 bp
Tssr84841	Chr9:46140131-46140142 (+)	209 bp
Tssr84842	Chr9:46140226-46140244 (+)	307 bp
Tssr84843	Chr9:46140249-46140278 (+)	336 bp
Tssr84844	Chr9:46140408-46140452 (+)	502 bp
Tssr84845	Chr9:46140460-46140489 (+)	547 bp
Tssr84846	Chr9:46140499-46140544 (+)	594 bp
Tssr84847	Chr9:46141120-46141206 (+)	1,235 bp
Tssr84848	Chr9:46141207-46141284 (+)	1,318 bp
Tssr84849	Chr9:46141299-46141320 (+)	1,382 bp
Tssr84850	Chr9:46141339-46141362 (+)	1,423 bp
Tssr84851	Chr9:46141383-46141397 (+)	1,462 bp
Tssr84852	Chr9:46141402-46141494 (+)	1,520 bp
Tssr84853	Chr9:46141500-46141528 (+)	1,586 bp
Tssr84854	Chr9:46141530-46141541 (+)	1,608 bp
Tssr84855	Chr9:46141549-46141561 (+)	1,627 bp
Tssr84856	Chr9:46141565-46141572 (+)	1,641 bp
Tssr84857	Chr9:46141683-46141694 (+)	1,761 bp
Tssr84858	Chr9:46141702-46141731 (+)	1,789 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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