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Apoc1 Gene Detail
Summary
  • Symbol
    Apoc1
  • Name
    apolipoprotein C-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:88053
    NCBI Gene: 11812
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19423405-19426584 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.94 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    237 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88053
 protein coding gene Chr7:19423405-19426585 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031791
 protein coding gene Chr7:17729276-17732496 (-)
A/J MGP_AJ_G0031767
 protein coding gene Chr7:17339170-17342344 (-)
AKR/J MGP_AKRJ_G0031693
 protein coding gene Chr7:17820906-17824082 (-)
BALB/cJ MGP_BALBcJ_G0031772
 protein coding gene Chr7:17544232-17547920 (-)
C3H/HeJ MGP_C3HHeJ_G0031494
 protein coding gene Chr7:18085243-18088443 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032238
 protein coding gene Chr7:18603394-18606568 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029304
 protein coding gene Chr7:18988663-18991822 (-)
CAST/EiJ MGP_CASTEiJ_G0030837
 protein coding gene Chr7:14521575-14524759 (-)
CBA/J MGP_CBAJ_G0031456
 protein coding gene Chr7:19280840-19284393 (-)
DBA/2J MGP_DBA2J_G0031611
 protein coding gene Chr7:17292997-17296172 (-)
FVB/NJ MGP_FVBNJ_G0031563
 protein coding gene Chr7:17161419-17164633 (-)
LP/J MGP_LPJ_G0031694
 protein coding gene Chr7:18040833-18044051 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031599
 protein coding gene Chr7:19101893-19105109 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032266
 protein coding gene Chr7:17433305-17437220 (-)
PWK/PhJ MGP_PWKPhJ_G0030561
 protein coding gene Chr7:14392757-14396069 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030388
 protein coding gene Chr7:12140972-12144207 (-)
WSB/EiJ MGP_WSBEiJ_G0030937
 protein coding gene Chr7:17650012-17653811 (-)



Homology
more
  • Human Ortholog
    APOC1, apolipoprotein C1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOC1, apolipoprotein C1
  • Synonyms
    APOC1B, Apo-CI, ApoC-I, apo-CIB, apoC-IB
  • Links
    NCBI Gene ID: 341
    neXtProt AC: NX_P02654
    UniProt: P02654

  • Chr Location
    19q13.32; chr19:44914247-44919349 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human APOC1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal serum lipid levels on a chow diet, develop hypercholesterolemia only when fed a high-fat/high-cholesterol diet, and show significant increases in the liver content of cholesteryl esters and triglycerides and in biliary cholesterol concentration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    12
  • cDNA Data
    151
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11812 NCBI Gene Model | MGI Sequence Detail 3180 C57BL/6J ±  kb
    transcript NM_007469 RefSeq | MGI Sequence Detail 554 ZRU/MplStud  
    polypeptide P34928 UniProt | EBI | MGI Sequence Detail 88 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 155
      Genomic 1
      cDNA 152
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1372
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:24996 Mahley RW, et al., Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 1;25(12):1277-94
    • Latest
      J:347607 Benzow K, et al., Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dementias in mice. Alzheimers Dement. 2024 Apr;20(4):3080-3087
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory