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Ar Gene Detail
Summary
  • Symbol
    Ar
  • Name
    androgen receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:88064
    NCBI Gene: 11835
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:97192375-97366821 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 42.82 cM
  • Mapping Data
    33 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2753 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88064
 protein coding gene ChrX:97192363-97366824 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035931
 protein coding gene ChrX:94519451-94700407 (+)
A/J MGP_AJ_G0035916
 protein coding gene ChrX:94631610-94809631 (+)
AKR/J MGP_AKRJ_G0035832
 protein coding gene ChrX:97292110-97471900 (+)
BALB/cJ MGP_BALBcJ_G0035899
 protein coding gene ChrX:93407432-93578928 (+)
C3H/HeJ MGP_C3HHeJ_G0035608
 protein coding gene ChrX:94992285-95167427 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036428
 protein coding gene ChrX:97458294-97643128 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033258
 protein coding gene ChrX:92480947-92650344 (+)
CAST/EiJ MGP_CASTEiJ_G0034895
 protein coding gene ChrX:79328711-79503668 (+)
CBA/J MGP_CBAJ_G0035583
 protein coding gene ChrX:100460337-100628022 (+)
DBA/2J MGP_DBA2J_G0035737
 protein coding gene ChrX:93888415-94059222 (+)
FVB/NJ MGP_FVBNJ_G0035675
 protein coding gene ChrX:93271509-93443758 (+)
LP/J MGP_LPJ_G0035827
 protein coding gene ChrX:95537760-95715093 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035710
 protein coding gene ChrX:104895192-105106596 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036455
 protein coding gene ChrX:94291304-94467544 (+)
PWK/PhJ MGP_PWKPhJ_G0034594
 protein coding gene ChrX:77021615-77190976 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034422
 protein coding gene ChrX:80192320-80361924 (+)
WSB/EiJ MGP_WSBEiJ_G0035034
 protein coding gene ChrX:92998626-93174570 (+)



Homology
more
  • Human Ortholog
    AR, androgen receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AR, androgen receptor
  • Synonyms
    AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
  • Links
    NCBI Gene ID: 367
    neXtProt AC: NX_P10275
    UniProt: P10275

  • Chr Location
    Xq12; chrX:67544021-67730619 (+)  GRCh38
  • MGI Vertebrate Homology
    Ar stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: AR
  • Gene Tree
    Ar
Human Diseases
more
  • Diseases
    3 with Ar mouse models; 14 with human AR associations

Human Disease Mouse Models
      
IDs
 View 8 models
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
 View 1 model
IDs
IDs
IDs
 View 1 model
IDs
IDs
IDs
IDs
 View 4 models
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    9 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    168 phenotypes from 16 alleles in 35 genetic backgrounds
    84 phenotypes from multigenic genotypes
    4 images
    362 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Hemizygous mutant males are androgen-resistant and therefore have small, undescended testes, and lack epididymal structures, vas deferens, and male accessory glands. They resemble females physically and behaviorally, but lack female reproductive organs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    188
  • GO References
    45
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1237
  • Tissues
    335
  • cDNA Data
    28
  • Literature Summary
    100
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046532 Ensembl Gene Model | MGI Sequence Detail 174447 C57BL/6J ±  kb
    transcript ENSMUST00000052837 Ensembl | MGI Sequence Detail 10048 Not Applicable  
    polypeptide ENSMUSP00000052648 Ensembl | MGI Sequence Detail 899 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 14
      cDNA 32
      Primer pair 14
      Other 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1384, MGD-MRK-15046, MGI:2148007
    References
    more
    • Summaries
      All 652
      Developmental Gene Expression 100
      Diseases 12
      Gene Ontology 45
      Phenotypes 362
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:347252 Kalyanaraman H, et al., A plasma membrane-associated form of the androgen receptor enhances nuclear androgen signaling in osteoblasts and prostate cancer cells. Sci Signal. 2024 Jan 30;17(821):eadi7861
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory