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Arnt Gene Detail
Summary
  • Symbol
    Arnt
  • Name
    aryl hydrocarbon receptor nuclear translocator
  • Synonyms
    bHLHe2, D3Ertd557e, ESTM42, Hif1b
  • Feature Type
    protein coding gene
  • IDs
    MGI:88071
    NCBI Gene: 11863
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95341699-95404551 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1484 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88071
 protein coding gene Chr3:95341674-95404551 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027584
 protein coding gene Chr3:96164939-96230153 (+)
A/J MGP_AJ_G0027543
 protein coding gene Chr3:93179523-93243362 (+)
AKR/J MGP_AKRJ_G0027510
 protein coding gene Chr3:95346598-95415006 (+)
BALB/cJ MGP_BALBcJ_G0027555
 protein coding gene Chr3:92957315-93021562 (+)
C3H/HeJ MGP_C3HHeJ_G0027288
 protein coding gene Chr3:95630161-95703914 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028003
 protein coding gene Chr3:99729366-99794128 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025343
 protein coding gene Chr3:89521424-89578755 (+)
CAST/EiJ MGP_CASTEiJ_G0026738
 protein coding gene Chr3:94898271-94964478 (+)
CBA/J MGP_CBAJ_G0027265
 protein coding gene Chr3:103369284-103444090 (+)
DBA/2J MGP_DBA2J_G0027404
 protein coding gene Chr3:92468814-92531138 (+)
FVB/NJ MGP_FVBNJ_G0027375
 protein coding gene Chr3:90548802-90610822 (+)
LP/J MGP_LPJ_G0027513
 protein coding gene Chr3:97480056-97546137 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027402
 protein coding gene Chr3:109473965-109537439 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028057
 protein coding gene Chr3:94992102-95053772 (+)
PWK/PhJ MGP_PWKPhJ_G0026466
 protein coding gene Chr3:92346323-92410458 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026287
 protein coding gene Chr3:93272409-93339229 (+)
WSB/EiJ MGP_WSBEiJ_G0026820
 protein coding gene Chr3:95379424-95441775 (+)



Homology
more
  • Human Ortholog
    ARNT, aryl hydrocarbon receptor nuclear translocator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARNT, aryl hydrocarbon receptor nuclear translocator
  • Synonyms
    ARNT1, bHLHe2, HIF1B, HIF-1-beta, HIF1-beta, HIF-1beta, HIF1BETA, TANGO
  • Links
    NCBI Gene ID: 405
    neXtProt AC: NX_P27540
    UniProt: P27540

  • Chr Location
    1q21.3; chr1:150809713-150876708 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ARNT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 7 alleles in 12 genetic backgrounds
    6 phenotypes from multigenic genotypes
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit loss of aryl hydrocarbon receptor and hypoxia-inducible factor 1 alpha gene induction, defective angiogenesis of the yolk sac and branchial arches, placental defects, and lethality by embryonic day 10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1347
  • Tissues
    406
  • cDNA Data
    32
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015522 Ensembl Gene Model | MGI Sequence Detail 62853 C57BL/6J ±  kb
    transcript ENSMUST00000102749 Ensembl | MGI Sequence Detail 2699 Not Applicable  
    polypeptide ENSMUSP00000099810 Ensembl | MGI Sequence Detail 791 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 9
      cDNA 39
      Primer pair 9
      Other 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-1394, MGD-MRK-8902, MGI:1261868, MGI:1334432
    References
    more
    • Summaries
      All 229
      Developmental Gene Expression 38
      Diseases 1
      Gene Ontology 29
      Phenotypes 87
    • Earliest
      J:12121 Brooks B, et al., Localization of a gene required for the nuclear translocation of the dioxin receptor to human chromosome 1 and mouse chromosome 3 and a human RFLP with MspI. Am J Hum Genet. 1989;45:A132 (Abstr.)
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory