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Atp1b1 Gene Detail
Summary
  • Symbol
    Atp1b1
  • Name
    ATPase, Na+/K+ transporting, beta 1 polypeptide
  • Synonyms
    Atpb, Atpb-1, sodium/potassium ATPase beta subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:88108
    NCBI Gene: 11931
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:164264678-164285924 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 71.75 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    546 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88108
 protein coding gene Chr1:164264668-164285924 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016685
 protein coding gene Chr1:169881030-169902416 (-)
A/J MGP_AJ_G0016666
 protein coding gene Chr1:162950566-162971948 (-)
AKR/J MGP_AKRJ_G0016632
 protein coding gene Chr1:167886583-167907810 (-)
BALB/cJ MGP_BALBcJ_G0016627
 protein coding gene Chr1:163447297-163468910 (-)
C3H/HeJ MGP_C3HHeJ_G0016451
 protein coding gene Chr1:168084182-168105497 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017088
 protein coding gene Chr1:175563586-175584830 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014797
 protein coding gene Chr1:154916214-154937730 (-)
CAST/EiJ MGP_CASTEiJ_G0016031
 protein coding gene Chr1:167707363-167746855 (-)
CBA/J MGP_CBAJ_G0016426
 protein coding gene Chr1:181826636-181850428 (-)
DBA/2J MGP_DBA2J_G0016532
 protein coding gene Chr1:161833132-161854974 (-)
FVB/NJ MGP_FVBNJ_G0016530
 protein coding gene Chr1:160297818-160319116 (-)
LP/J MGP_LPJ_G0016603
 protein coding gene Chr1:170961639-170984179 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016555
 protein coding gene Chr1:189325397-189348503 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017124
 protein coding gene Chr1:167731121-167752355 (-)
PWK/PhJ MGP_PWKPhJ_G0015817
 protein coding gene Chr1:161013692-161052235 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015604
 protein coding gene Chr1:166577343-166622824 (-)
WSB/EiJ MGP_WSBEiJ_G0016093
 protein coding gene Chr1:167883497-167906041 (-)



Homology
more
  • Human Ortholog
    ATP1B1, ATPase Na+/K+ transporting subunit beta 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP1B1, ATPase Na+/K+ transporting subunit beta 1
  • Synonyms
    ATP1B
  • Links
    NCBI Gene ID: 481
    neXtProt AC: NX_P05026
    UniProt: P05026

  • Chr Location
    1q24.2; chr1:169105697-169310992 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ATP1B1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 3 alleles in 6 genetic backgrounds
    9 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in cardiac tissue exhibit age-related cardiac hypertrophy and reduced cardiac function, insensitivity to ouabain, and increased heart dysfunction following aortic constriction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    87
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1426
  • Tissues
    398
  • cDNA Data
    24
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026576 Ensembl Gene Model | MGI Sequence Detail 21247 C57BL/6J ±  kb
    transcript ENSMUST00000027863 Ensembl | MGI Sequence Detail 2580 Not Applicable  
    polypeptide ENSMUSP00000027863 Ensembl | MGI Sequence Detail 304 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000004439 sodium/potassium-transporting ATPase subunit beta-1
      (term hierarchy)
    • InterPro Domains
      IPR000402 Sodium/potassium-transporting ATPase subunit beta
      IPR038702 Sodium/potassium-transporting ATPase subunit beta superfamily
    • GlyGen
      P14094 4 sites, 17 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 29
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-1460, MGD-MRK-1473, MGD-MRK-1474
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 28
      Gene Ontology 17
      Phenotypes 19
    • Earliest
      J:19611 Mercer RW, et al., Rat-brain Na,K-ATPase beta-chain gene: primary structure, tissue-specific expression, and amplification in ouabain-resistant HeLa C+ cells. Mol Cell Biol. 1986 Nov;6(11):3884-90
    • Latest
      J:347984 Naillat F, et al., Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167180
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory