Bdkrb1 MGI Mouse Gene Detail - MGI:88144 - bradykinin receptor, beta 1

Symbol

Bdkrb1
Name

bradykinin receptor, beta 1
Synonyms

B1R, kinin B1

Feature Type

protein coding gene
IDs

MGI:88144
NCBI Gene: 12061
Alliance

gene page

Sequence Map

Chr12:105570350-105571770 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 55.81 cM, cytoband F1
Mapping Data

1 experiment

SNPs within 2kb

179 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88144	protein coding gene	Chr12:105569344-105571770 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020092	protein coding gene	Chr12:107484180-107486523 (+)
A/J	MGP_AJ_G0020046	protein coding gene	Chr12:103468965-103471308 (+)
AKR/J	MGP_AKRJ_G0020022	protein coding gene	Chr12:106472416-106474548 (+)
BALB/cJ	MGP_BALBcJ_G0020032	protein coding gene	Chr12:103886987-103889326 (+)
C3H/HeJ	MGP_C3HHeJ_G0019834	protein coding gene	Chr12:106901577-106903920 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020477	protein coding gene	Chr12:110795946-110798301 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018089	protein coding gene	Chr12:100079016-100081353 (+)
CAST/EiJ	MGP_CASTEiJ_G0019376	protein coding gene	Chr12:101704769-101707152 (+)
CBA/J	MGP_CBAJ_G0019801	protein coding gene	Chr12:115185920-115188052 (+)
DBA/2J	MGP_DBA2J_G0019918	protein coding gene	Chr12:102995072-102997407 (+)
FVB/NJ	MGP_FVBNJ_G0019903	protein coding gene	Chr12:101782382-101786184 (+)
LP/J	MGP_LPJ_G0019993	protein coding gene	Chr12:107381867-107384200 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019941	protein coding gene	Chr12:118589540-118591869 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020506	protein coding gene	Chr12:105854139-105856484 (+)
PWK/PhJ	MGP_PWKPhJ_G0019135	protein coding gene	Chr12:97588009-97590381 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018939	protein coding gene	Chr12:100090334-100092678 (+)
WSB/EiJ	MGP_WSBEiJ_G0019433	protein coding gene	Chr12:106818090-106820436 (+)

Human Ortholog

BDKRB1, bradykinin receptor B1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BDKRB1, bradykinin receptor B1
Synonyms

B1BKR, B1R, BKB1R, BKR1, BRADYB1
Links

HGNC:1029

NCBI Gene ID: 623

neXtProt AC: NX_P46663

UniProt: P46663
Chr Location

14q32.2; chr14:96256210-96268967 (+) GRCh38

MGI Vertebrate Homology

Bdkrb1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BDKRB1
Gene Tree

Bdkrb1

Diseases

3 with human BDKRB1 associations

				Human Disease	Mouse Models
				end stage renal disease IDs end stage renal disease DOID:783
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				pulmonary fibrosis IDs pulmonary fibrosis DOID:3770 MESH:D011658 NCI:C26869 UMLS_CUI:C0034069

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 3 alleles in 3 genetic backgrounds
5 phenotypes from multigenic genotypes
60 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

6
Genomic Mutations

2 involving Bdkrb1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one null allele display hypoalgesia and altered inflammatory responses while those homozygous for another are reported to have a normal phenotype.

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All GO Annotations

26
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

53
cDNA Data

4
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN bdkrb1

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All Sequences

33
RefSeq

2
UniProt

3
CCDS

CCDS26155.1

Ensembl

ENSMUSG00000041347 (Evidence)
NCBI Gene

12061

			Length	Strain/Species	Flank
genomic	12061	NCBI Gene Model \| MGI Sequence Detail	1421	C57BL/6J	± kb
transcript	NM_007539	RefSeq \| MGI Sequence Detail	1421	C57BL/6
polypeptide	Q61125	UniProt \| EBI \| MGI Sequence Detail	334	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001171 B1 bradykinin receptor

(term hierarchy)
InterPro Domains

IPR001186 Bradykinin receptor B1

IPR000496 Bradykinin receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR050119 G-protein coupled receptor 1

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Q61125 3 sites

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All nucleic 8

Genomic 2

cDNA 4

Primer pair 2

Microarray probesets 3

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MGD-MRK-1533

Summaries

All 96

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 60
Earliest

J:16469 McIntyre P, et al., Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity [published erratum appears in Mol Pharmacol 1994 Mar;45(3):561]. Mol Pharmacol. 1993 Aug;44(2):346-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24