Blk MGI Mouse Gene Detail - MGI:88169

Symbol

Blk
Name

B lymphoid kinase

Feature Type

protein coding gene
IDs

MGI:88169
NCBI Gene: 12143
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr14:63610285-63654486 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 33.25 cM
Mapping Data

5 experiments

SNPs within 2kb

1402 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88169	protein coding gene	Chr14:63610285-63654636 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021460	protein coding gene	Chr14:57889929-57905502 (-)
A/J	MGP_AJ_G0021419	protein coding gene	Chr14:56580685-56625933 (-)
AKR/J	MGP_AKRJ_G0021395	protein coding gene	Chr14:58591473-58635518 (-)
BALB/cJ	MGP_BALBcJ_G0021425	protein coding gene	Chr14:56535824-56580155 (-)
C3H/HeJ	MGP_C3HHeJ_G0021202	protein coding gene	Chr14:58204286-58248972 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021864	protein coding gene	Chr14:60640515-60685447 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019404	protein coding gene	Chr14:54525996-54568835 (-)
CAST/EiJ	MGP_CASTEiJ_G0020719	protein coding gene	Chr14:54656496-54706345 (-)
CBA/J	MGP_CBAJ_G0021169	protein coding gene	Chr14:62441763-62500105 (-)
DBA/2J	MGP_DBA2J_G0021292	protein coding gene	Chr14:56254096-56299363 (-)
FVB/NJ	MGP_FVBNJ_G0021271	protein coding gene	Chr14:55641271-55687698 (-)
LP/J	MGP_LPJ_G0021367	protein coding gene	Chr14:58912714-58960600 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021300	protein coding gene	Chr14:61698030-61742373 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021887	protein coding gene	Chr14:57743606-57792820 (-)
PWK/PhJ	MGP_PWKPhJ_G0020463	protein coding gene	Chr14:52924349-52969748 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020296	protein coding gene	Chr14:53709163-53753545 (-)
WSB/EiJ	MGP_WSBEiJ_G0020772	protein coding gene	Chr14:58060738-58114609 (-)

Human Ortholog

BLK, BLK proto-oncogene, Src family tyrosine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BLK, BLK proto-oncogene, Src family tyrosine kinase
Synonyms

MODY11
Links

HGNC:1057

NCBI Gene ID: 640

neXtProt AC: NX_P51451

UniProt: P51451
Chr Location

8p23.1; chr8:11486894-11564599 (+) GRCh38

MGI Vertebrate Homology

Blk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BLK
Gene Tree

Blk

Diseases

2 with human BLK associations

				Human Disease	Mouse Models
				maturity-onset diabetes of the young type 11 IDs maturity-onset diabetes of the young type 11 DOID:0111109 OMIM:613375
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
6 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

4
Genomic Mutations

1 involving Blk
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene does not result in a phenotype.

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All GO Annotations

22
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

779
Tissues

50
cDNA Data

29
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS27200.1

Ensembl

ENSMUSG00000014453 (Evidence)
NCBI Gene

12143

			Length	Strain/Species	Flank
genomic	ENSMUSG00000014453	Ensembl Gene Model \| MGI Sequence Detail	44202	C57BL/6J	± kb
transcript	ENSMUST00000014597	Ensembl \| MGI Sequence Detail	2326	Not Applicable
polypeptide	ENSMUSP00000014597	Ensembl \| MGI Sequence Detail	499	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004758 tyrosine-protein kinase BLK

(term hierarchy)
PDB

1BLJ, 1BLK
EC

2.7.10.2
InterPro Domains

IPR050198 Non-receptor tyrosine kinases involved in cell signaling

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR035853 Tyrosine-protein kinase Blk, SH2 domain

IPR020635 Tyrosine-protein kinase, catalytic domain
GlyGen

P16277 1 site, 1 O-linked glycan (1 site)

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All nucleic 35

Genomic 5

cDNA 29

Primer pair 1

Microarray probesets 4

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MGD-MRK-1577

Summaries

All 65

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 20
Earliest

J:10210 Dymecki SM, et al., Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science. 1990 Jan 19;247(4940):332-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Blk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129191	Chr14:63656269-63656284 (-)	-1,791 bp
Tssr129190	Chr14:63655896-63655923 (-)	-1,424 bp
Tssr129189	Chr14:63654574-63654587 (-)	-95 bp
Tssr129188	Chr14:63654522-63654533 (-)	-42 bp
Tssr129187	Chr14:63654478-63654508 (-)	-7 bp
Tssr129186	Chr14:63654266-63654294 (-)	206 bp
Tssr129185	Chr14:63642700-63642711 (-)	11,780 bp
Tssr129184	Chr14:63642677-63642690 (-)	11,802 bp
Tssr129183	Chr14:63615320-63615347 (-)	39,152 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24