Bmfr1 QTL Detail

Summary

• Symbol
  Bmfr1
• Name
  B cell maturation factor responsiveness 1
• Synonyms
  Bmfr-1

• Feature Type
  QTL
• IDs
  MGI:88172
  NCBI Gene: 110636

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 4, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  4 experiments

Mutations,
Alleles, and
Phenotypes

This locus controls splenic B-cells ability to differentiate into antibody-secreting cells in response to B-cell maturation factors up to one month of age. Bmfr2 controls the response after one month of age. Strains differ in response alleles, but both loci show the same strain distribution pattern.

Sequences &
Gene Models

• NCBI Gene
  110636

Other
Accession IDs

MGD-MRK-1584, MGD-MRK-1586

References

• Summaries
  All 5
• Earliest
  J:8143 Sidman CL, et al., Two loci affecting B cell responses to B cell maturation factors. J Exp Med. 1986 Jan 1;163(1):116-28
• Latest
  J:65671 Araujo LM, et al., NKT lymphocyte ontogeny and function are impaired in low antibody-producer Biozzi mice: gene mapping in the interval-specific congenic strains raised for immunomodulatory genes. Int Immunol. 2000 Nov;12(11):1613-22