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Bmp2 Gene Detail
Summary
  • Symbol
    Bmp2
  • Name
    bone morphogenetic protein 2
  • Synonyms
    Bmp2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:88177
    NCBI Gene: 12156
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:133394079-133404805 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 65.21 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    285 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88177
 protein coding gene Chr2:133394079-133404816 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026551
 protein coding gene Chr2:137213173-137224742 (+)
A/J MGP_AJ_G0026515
 protein coding gene Chr2:131604920-131616052 (+)
AKR/J MGP_AKRJ_G0026489
 protein coding gene Chr2:135421304-135431997 (+)
BALB/cJ MGP_BALBcJ_G0026527
 protein coding gene Chr2:132026375-132037421 (+)
C3H/HeJ MGP_C3HHeJ_G0026270
 protein coding gene Chr2:135865028-135876338 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026972
 protein coding gene Chr2:141374428-141387660 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024349
 protein coding gene Chr2:126294214-126305288 (+)
CAST/EiJ MGP_CASTEiJ_G0025731
 protein coding gene Chr2:136187860-136197803 (+)
CBA/J MGP_CBAJ_G0026250
 protein coding gene Chr2:146628611-146644765 (+)
DBA/2J MGP_DBA2J_G0026384
 protein coding gene Chr2:130985371-130997000 (+)
FVB/NJ MGP_FVBNJ_G0026348
 protein coding gene Chr2:129619214-129629877 (+)
LP/J MGP_LPJ_G0026488
 protein coding gene Chr2:137440579-137451631 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026368
 protein coding gene Chr2:150388758-150411077 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027027
 protein coding gene Chr2:135381378-135392099 (+)
PWK/PhJ MGP_PWKPhJ_G0025467
 protein coding gene Chr2:130598618-130607892 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025269
 protein coding gene Chr2:134531705-134543829 (+)
WSB/EiJ MGP_WSBEiJ_G0025805
 protein coding gene Chr2:136306374-136319704 (+)



Homology
more
  • Human Ortholog
    BMP2, bone morphogenetic protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMP2, bone morphogenetic protein 2
  • Synonyms
    BDA2, BMP2A, SSFSC, SSFSC1
  • Links
    NCBI Gene ID: 650
    neXtProt AC: NX_P12643
    UniProt: P12643

  • Chr Location
    20p12.3; chr20:6767686-6780246 (+)  GRCh38
Human Diseases
more
  • Diseases
    7 with human BMP2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    79 phenotypes from 9 alleles in 12 genetic backgrounds
    57 phenotypes from multigenic genotypes
    5 images
    88 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die at embryonic day 7.5-9 with failure of the proamniotic canal to close and abnormal development of the heart in the exocoelomic cavity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    207
  • GO References
    73
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2135
  • Tissues
    790
  • cDNA Data
    39
  • Literature Summary
    528
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027358 Ensembl Gene Model | MGI Sequence Detail 10727 C57BL/6J ±  kb
    transcript ENSMUST00000028836 Ensembl | MGI Sequence Detail 3555 Not Applicable  
    polypeptide ENSMUSP00000028836 Ensembl | MGI Sequence Detail 394 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000000164 bone morphogenetic protein 2
      (term hierarchy)
    • InterPro Domains
      IPR047953 Bone morphogenetic protein 2, TGF-beta-like domain
      IPR029034 Cystine-knot cytokine
      IPR001111 TGF-beta, propeptide
      IPR017948 Transforming growth factor beta, conserved site
      IPR001839 Transforming growth factor-beta, C-terminal
      IPR015615 Transforming growth factor-beta-related
    • GlyGen
      P21274 4 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 149
      Genomic 5
      cDNA 49
      Primer pair 36
      Other 59

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1593, MGD-MRK-1595, MGI:2138975
    References
    more
    • Summaries
      All 810
      Developmental Gene Expression 528
      Gene Ontology 73
      Phenotypes 88
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:353576 Lin Y, et al., Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation. Circulation. 2024 Feb 20;149(8):605-626
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory