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Bmyc Gene Detail
Summary
  • Symbol
    Bmyc
  • Name
    brain expressed myelocytomatosis oncogene
  • Synonyms
    2900002K07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88184
    NCBI Gene: 107771
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25596891-25597733 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.82 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88184
 protein coding gene Chr2:25596751-25597733 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025467
 protein coding gene Chr2:23626625-23627607 (+)
A/J MGP_AJ_G0025444
 protein coding gene Chr2:22710665-22711647 (+)
AKR/J MGP_AKRJ_G0025414
 protein coding gene Chr2:23460245-23461227 (+)
BALB/cJ MGP_BALBcJ_G0025440
 protein coding gene Chr2:22817113-22818095 (+)
C3H/HeJ MGP_C3HHeJ_G0025201
 protein coding gene Chr2:23397973-23398955 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025884
 protein coding gene Chr2:24380229-24381211 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023295
 protein coding gene Chr2:21607821-21608805 (+)
CAST/EiJ MGP_CASTEiJ_G0024664
 protein coding gene Chr2:23269840-23270822 (+)
CBA/J MGP_CBAJ_G0025179
 protein coding gene Chr2:25211901-25212883 (+)
DBA/2J MGP_DBA2J_G0025312
 protein coding gene Chr2:22552162-22553144 (+)
FVB/NJ MGP_FVBNJ_G0025274
 protein coding gene Chr2:22288160-22289142 (+)
LP/J MGP_LPJ_G0025398
 protein coding gene Chr2:23557969-23558951 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025305
 protein coding gene Chr2:25388900-25389882 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025943
 protein coding gene Chr2:23424192-23425174 (+)
PWK/PhJ MGP_PWKPhJ_G0024412
 protein coding gene Chr2:22351231-22352213 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024212
 protein coding gene Chr2:23552859-23553841 (+)
WSB/EiJ MGP_WSBEiJ_G0024733
 protein coding gene Chr2:23484025-23485007 (+)



Homology
more
  • Human Ortholog
    MYC, MYC proto-oncogene, bHLH transcription factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYC, MYC proto-oncogene, bHLH transcription factor
  • Synonyms
    bHLHe39, c-Myc, MRTL, MYCC
  • Links
    NCBI Gene ID: 4609
    neXtProt AC: NX_P01106
    UniProt: P01106

  • Chr Location
    8q24.21; chr8:127735434-127742951 (+)  GRCh38
Human Diseases
more
  • Diseases
    9 with human MYC associations

Human Disease Mouse Models
      
IDs
IDs
IDs
 View 7 models
IDs
 View 4 models
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial lethality, reduced body weight in male mice and abnormal male reproductive system morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    58
  • cDNA Data
    43
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107771 NCBI Gene Model | MGI Sequence Detail 843 C57BL/6J ±  kb
    transcript NM_023326 RefSeq | MGI Sequence Detail 861 C57BL/6  
    polypeptide Q6P8Z1 UniProt | EBI | MGI Sequence Detail 170 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 4
      cDNA 43
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1606, MGI:1914503, MGI:2139289
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 1
    • Earliest
      J:4488 Ingvarsson S, et al., Chromosome localization and expression pattern of Lmyc and Bmyc in murine embryonal carcinoma cells. Oncogene. 1988 Dec;3(6):679-85
    • Latest
      J:238877 Chen S, et al., Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium. Development. 2015 Mar 15;142(6):1180-92
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory