C1qc MGI Mouse Gene Detail - MGI:88225 - complement component 1, q subcomponent, C chain

Symbol

C1qc
Name

complement component 1, q subcomponent, C chain
Synonyms

C1qg

Feature Type

protein coding gene
IDs

MGI:88225
NCBI Gene: 12262
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr4:136617115-136620225 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 69.05 cM
Mapping Data

5 experiments

SNPs within 2kb

191 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88225	protein coding gene	Chr4:136617115-136620376 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028974	protein coding gene	Chr4:139482777-139486038 (-)
A/J	MGP_AJ_G0028933	protein coding gene	Chr4:133547901-133551171 (-)
AKR/J	MGP_AKRJ_G0028885	protein coding gene	Chr4:137393235-137396505 (-)
BALB/cJ	MGP_BALBcJ_G0028957	protein coding gene	Chr4:134212259-134215529 (-)
C3H/HeJ	MGP_C3HHeJ_G0028671	protein coding gene	Chr4:137689525-137692795 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029398	protein coding gene	Chr4:144460778-144464039 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026669	protein coding gene	Chr4:126574576-126577848 (-)
CAST/EiJ	MGP_CASTEiJ_G0028103	protein coding gene	Chr4:135839409-135842684 (-)
CBA/J	MGP_CBAJ_G0028636	protein coding gene	Chr4:148452682-148455952 (-)
DBA/2J	MGP_DBA2J_G0028785	protein coding gene	Chr4:133951435-133954705 (-)
FVB/NJ	MGP_FVBNJ_G0028752	protein coding gene	Chr4:132911526-132914796 (-)
LP/J	MGP_LPJ_G0028884	protein coding gene	Chr4:139569283-139572544 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028778	protein coding gene	Chr4:152590382-152593652 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029436	protein coding gene	Chr4:137873961-137877222 (-)
PWK/PhJ	MGP_PWKPhJ_G0027823	protein coding gene	Chr4:130743997-130747267 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027649	protein coding gene	Chr4:133665630-133668871 (-)
WSB/EiJ	MGP_WSBEiJ_G0028181	protein coding gene	Chr4:138031722-138034992 (-)

Human Ortholog

C1QC, complement C1q C chain

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C1QC, complement C1q C chain
Synonyms

C1Q-C, C1QD3, C1QG
Links

HGNC:1245

NCBI Gene ID: 714

neXtProt AC: NX_P02747

UniProt: P02747
Chr Location

1p36.12; chr1:22643014-22648110 (+) GRCh38

MGI Vertebrate Homology

C1qc stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: C1QC
Gene Tree

C1qc

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

5
Targeted

1
Genomic Mutations

3 involving C1qc
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

3
cDNA Data

42
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN c1qc

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All Sequences

38
RefSeq

4
UniProt

1
CCDS

CCDS18811.1

Ensembl

ENSMUSG00000036896 (Evidence)
NCBI Gene

12262

			Length	Strain/Species	Flank
genomic	12262	NCBI Gene Model \| MGI Sequence Detail	3111	C57BL/6J	± kb
transcript	NM_001419959	RefSeq \| MGI Sequence Detail	1102	ZRU/MplStud
polypeptide	Q02105	UniProt \| EBI \| MGI Sequence Detail	246	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004878 complement C1q subcomponent subunit C

(term hierarchy)
InterPro Domains

IPR001073 C1q domain

IPR050392 Collagen/C1q domain-containing

IPR008160 Collagen triple helix repeat

IPR008983 Tumour necrosis factor-like domain superfamily
GlyGen

Q02105 1 site, 1 O-linked glycan (1 site)

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All nucleic 47

Genomic 3

cDNA 43

Primer pair 1

Microarray probesets 3

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MGD-MRK-1698, MGI:2140252

Summaries

All 50

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 11
Earliest

J:3065 Petry F, et al., Isolation, sequence analysis and characterization of cDNA clones coding for the C chain of mouse C1q. Sequence similarity of complement subcomponent C1q, collagen type VIII and type X and precerebellin. Eur J Biochem. 1992 Oct 1;209(1):129-34
Latest

J:345949 Xu D, et al., Complement in breast milk modifies offspring gut microbiota to promote infant health. Cell. 2024 Feb 1;187(3):750-763.e20

TSS for C1qc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44090	Chr4:136620403-136620409 (-)	-181 bp
Tssr44089	Chr4:136620178-136620248 (-)	12 bp
Tssr44088	Chr4:136620172-136620175 (-)	51 bp
Tssr44087	Chr4:136620161-136620165 (-)	62 bp
Tssr44086	Chr4:136619796-136619904 (-)	375 bp
Tssr44085	Chr4:136617815-136617818 (-)	2,408 bp
Tssr44084	Chr4:136617750-136617759 (-)	2,470 bp
Tssr44083	Chr4:136617728-136617733 (-)	2,494 bp
Tssr44082	Chr4:136617682-136617695 (-)	2,536 bp
Tssr44081	Chr4:136617665-136617676 (-)	2,554 bp
Tssr44080	Chr4:136617637-136617654 (-)	2,579 bp
Tssr44079	Chr4:136617614-136617626 (-)	2,605 bp
Tssr44078	Chr4:136617594-136617605 (-)	2,625 bp
Tssr44077	Chr4:136617561-136617566 (-)	2,661 bp
Tssr44076	Chr4:136617468-136617473 (-)	2,754 bp
Tssr44075	Chr4:136617444-136617455 (-)	2,775 bp
Tssr44074	Chr4:136617399-136617410 (-)	2,820 bp
Tssr44073	Chr4:136617367-136617374 (-)	2,854 bp
Tssr44072	Chr4:136617310-136617353 (-)	2,893 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24