C4bp MGI Mouse Gene Detail - MGI:88229 - complement component 4 binding protein

Symbol

C4bp
Name

complement component 4 binding protein

Feature Type

protein coding gene
IDs

MGI:88229
NCBI Gene: 12269
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:130562510-130589365 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 56.89 cM
Mapping Data

22 experiments

SNPs within 2kb

364 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88229	protein coding gene	Chr1:130562510-130589369 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016436	protein coding gene	Chr1:134020683-134050145 (-)
A/J	MGP_AJ_G0016419	protein coding gene	Chr1:129068931-129096051 (-)
AKR/J	MGP_AKRJ_G0016384	protein coding gene	Chr1:132866623-132900793 (-)
BALB/cJ	MGP_BALBcJ_G0016379	protein coding gene	Chr1:129401649-129428451 (-)
C3H/HeJ	MGP_C3HHeJ_G0016205	protein coding gene	Chr1:133008131-133034915 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016840	protein coding gene	Chr1:139010851-139038324 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014554	protein coding gene	Chr1:122222919-122248322 (-)
CAST/EiJ	MGP_CASTEiJ_G0015785	protein coding gene	Chr1:131994866-132024096 (-)
CBA/J	MGP_CBAJ_G0016177	protein coding gene	Chr1:143794171-143826035 (-)
DBA/2J	MGP_DBA2J_G0016284	protein coding gene	Chr1:128032616-128059607 (-)
FVB/NJ	MGP_FVBNJ_G0016283	protein coding gene	Chr1:126677264-126704186 (-)
LP/J	MGP_LPJ_G0016355	protein coding gene	Chr1:135337183-135365112 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016308	protein coding gene	Chr1:149569117-149606299 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016876	protein coding gene	Chr1:132635601-132663397 (-)
PWK/PhJ	MGP_PWKPhJ_G0015571	protein coding gene	Chr1:127001102-127028437 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015358	protein coding gene	Chr1:131556818-131586612 (-)
WSB/EiJ	MGP_WSBEiJ_G0015847	protein coding gene	Chr1:132595425-132622226 (-)

Human Ortholog

C4BPA, complement component 4 binding protein alpha

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C4BPA, complement component 4 binding protein alpha
Synonyms

C4BP, PRP
Links

HGNC:1325

NCBI Gene ID: 722

neXtProt AC: NX_P04003

UniProt: P04003
Chr Location

1q32.2; chr1:207104233-207144972 (+) GRCh38

MGI Vertebrate Homology

C4bp stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: C4BPA
Gene Tree

C4bp

Diseases

1 with human C4BPA associations

				Human Disease	Mouse Models
				COVID-19 IDs COVID-19 DOID:0080600 ICD10CM:U07.1 MESH:D000086382 NCI:C171133 UMLS_CUI:C5203670

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving C4bp
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice exhibit normal fertility and spermatozoa morphology and function. Mice homozygous for the same allele exhibit increase IL6 serum levels in response to LPS injection.

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

798
Tissues

54
cDNA Data

46
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

59
RefSeq

16
UniProt

5
CCDS

CCDS35700.1

Ensembl

ENSMUSG00000026405 (Evidence)
NCBI Gene

12269

			Length	Strain/Species	Flank
genomic	12269	NCBI Gene Model \| MGI Sequence Detail	26856	C57BL/6J	± kb
transcript	NM_001419982	RefSeq \| MGI Sequence Detail	3058	ZRU/MplStud
polypeptide	P08607	UniProt \| EBI \| MGI Sequence Detail	469	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000030465 C4b-binding protein alpha chain

(term hierarchy)
InterPro Domains

IPR040514 C4b-binding protein alpha, oligomerization domain

IPR050350 Complement & Cell Adhesion Regulators

IPR000436 Sushi/SCR/CCP domain

IPR035976 Sushi/SCR/CCP superfamily
GlyGen

P08607 7 sites, 5 N-linked glycans (4 sites)

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All nucleic 58

Genomic 9

cDNA 47

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-1702, MGI:2138170

Summaries

All 64

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 14
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for C4bp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13517	Chr1:130589391-130589400 (-)	-31 bp
Tssr13516	Chr1:130589350-130589374 (-)	3 bp
Tssr13515	Chr1:130589321-130589346 (-)	31 bp
Tssr13514	Chr1:130589302-130589320 (-)	54 bp
Tssr13513	Chr1:130589290-130589301 (-)	69 bp
Tssr13512	Chr1:130589261-130589276 (-)	96 bp
Tssr13511	Chr1:130589228-130589248 (-)	127 bp
Tssr13510	Chr1:130575205-130575210 (-)	14,157 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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