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C6 Gene Detail
Summary
  • Symbol
    C6
  • Name
    complement component 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:88233
    NCBI Gene: 12274
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:4756550-4833527 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 1.97 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1609 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88233
 protein coding gene Chr15:4756550-4844449 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021687
 protein coding gene Chr15:1603668-1684158 (+)
A/J MGP_AJ_G0021647
 protein coding gene Chr15:1627745-1712167 (+)
AKR/J MGP_AKRJ_G0021625
 protein coding gene Chr15:1619445-1704603 (+)
BALB/cJ MGP_BALBcJ_G0021654
 protein coding gene Chr15:1565762-1649640 (+)
C3H/HeJ MGP_C3HHeJ_G0021430
 protein coding gene Chr15:1649850-1735650 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022093
 protein coding gene Chr15:1699238-1774030 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019631
 protein coding gene Chr15:1408794-1483952 (+)
CAST/EiJ MGP_CASTEiJ_G0020947
 protein coding gene Chr15:1626227-1711847 (+)
CBA/J MGP_CBAJ_G0021399
 protein coding gene Chr15:1735509-1816355 (+)
DBA/2J MGP_DBA2J_G0021523
 protein coding gene Chr15:1576339-1660294 (+)
FVB/NJ MGP_FVBNJ_G0021501
 protein coding gene Chr15:1528430-1609335 (+)
LP/J MGP_LPJ_G0021590
 protein coding gene Chr15:1552340-1633583 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021527
 protein coding gene Chr15:1847154-1952328 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022116
 protein coding gene Chr15:1624306-1704901 (+)
PWK/PhJ MGP_PWKPhJ_G0020690
 protein coding gene Chr15:1589402-1675328 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020528
 protein coding gene Chr15:1624607-1692864 (+)
WSB/EiJ MGP_WSBEiJ_G0021002
 protein coding gene Chr15:1580796-1663411 (+)



Homology
more
  • Human Ortholog
    C6, complement C6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C6, complement C6
  • Links
    NCBI Gene ID: 729
    neXtProt AC: NX_P13671
    UniProt: P13671

  • Chr Location
    5p13.1; chr5:41142116-41261469 (-)  GRCh38
  • MGI Vertebrate Homology
    C6 stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: C6
  • Gene Tree
    C6
Human Diseases
more
  • Diseases
    1 with human C6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation exhibit decreased susceptibility to ischemia reperfusion-induced renal injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    27
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12274 NCBI Gene Model | MGI Sequence Detail 76978 C57BL/6J ±  kb
transcript NM_016704 RefSeq | MGI Sequence Detail 2863 ZRU/MplStud  
polypeptide NP_057913 RefSeq | MGI Sequence Detail 769 ZRU/MplStud  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR048828 Complement component C6, KAZAL domain
    IPR048831 Complement components C8A/B/C6, EGF-like domain
    IPR003884 Factor I / membrane attack complex
    IPR002350 Kazal domain
    IPR036055 LDL receptor-like superfamily
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR001862 Membrane attack complex component/perforin/complement C9
    IPR020863 Membrane attack complex component/perforin domain, conserved site
    IPR020864 Membrane attack complex component/perforin (MACPF) domain
    IPR000436 Sushi/SCR/CCP domain
    IPR035976 Sushi/SCR/CCP superfamily
    IPR000884 Thrombospondin type-1 (TSP1) repeat
    IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Molecular
Reagents
less
  • All nucleic 28
    cDNA 27
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1711, MGI:2146192
References
more
  • Summaries
    All 54
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 25
  • Earliest
    J:7685 Hayakawa JI, et al., Genetic polymorphism of the sixth component of complement (C6) in mice. Immunogenetics. 1984;20(6):633-8
  • Latest
    J:333343 Linde IL, et al., Neutrophil-activating therapy for the treatment of cancer. Cancer Cell. 2023 Feb 13;41(2):356-372.e10
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory