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Anxa2 Gene Detail
Summary
  • Symbol
    Anxa2
  • Name
    annexin A2
  • Synonyms
    36-kDa calelectrin, annexin II, Cal1h, lipocortin II
  • Feature Type
    protein coding gene
  • IDs
    MGI:88246
    NCBI Gene: 12306
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:69360978-69399074 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 38.58 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1245 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88246
 protein coding gene Chr9:69360902-69399077 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034992
 protein coding gene Chr9:69447521-69486746 (+)
A/J MGP_AJ_G0034973
 protein coding gene Chr9:67060717-67098823 (+)
AKR/J MGP_AKRJ_G0034902
 protein coding gene Chr9:68651080-68689198 (+)
BALB/cJ MGP_BALBcJ_G0034965
 protein coding gene Chr9:66788383-66826852 (+)
C3H/HeJ MGP_C3HHeJ_G0034674
 protein coding gene Chr9:69157475-69196133 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035484
 protein coding gene Chr9:71306750-71346017 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032395
 protein coding gene Chr9:66637322-66676427 (+)
CAST/EiJ MGP_CASTEiJ_G0033996
 protein coding gene Chr9:69408426-69448008 (+)
CBA/J MGP_CBAJ_G0034647
 protein coding gene Chr9:73808101-73847458 (+)
DBA/2J MGP_DBA2J_G0034806
 protein coding gene Chr9:66815736-66853918 (+)
FVB/NJ MGP_FVBNJ_G0034748
 protein coding gene Chr9:66131154-66169284 (+)
LP/J MGP_LPJ_G0034887
 protein coding gene Chr9:69710848-69748955 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034789
 protein coding gene Chr9:74919904-74960386 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035506
 protein coding gene Chr9:68788281-68828054 (+)
PWK/PhJ MGP_PWKPhJ_G0033700
 protein coding gene Chr9:67030007-67070484 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033533
 protein coding gene Chr9:69096615-69138775 (+)
WSB/EiJ MGP_WSBEiJ_G0034108
 protein coding gene Chr9:68680269-68720721 (+)



Homology
more
  • Human Ortholog
    ANXA2, annexin A2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANXA2, annexin A2
  • Synonyms
    ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV
  • Links
    NCBI Gene ID: 302
    neXtProt AC: NX_P07355
    UniProt: P07355

  • Chr Location
    15q22.2; chr15:60347134-60402883 (-)  GRCh38
  • Human Ortholog
    ANXA2P2, annexin A2 pseudogene 2
  • Synonyms
    ANX2L2, ANX2P2, LPC2B
  • Links
    NCBI Gene ID: 304
    UniProt: A6NMY6

  • Chr Location
    9p13.3; chr9:33624225-33625534 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ANXA2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are viable and fertile but suffer from growth deficits, impaired angiogenesis, and increased susceptibility to thrombosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    118
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    30
  • cDNA Data
    461
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12306 NCBI Gene Model | MGI Sequence Detail 38097 C57BL/6J ±  kb
    transcript NM_001409577 RefSeq | MGI Sequence Detail 1393 ZRU/MplStud  
    polypeptide P07356 UniProt | EBI | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 469
      Genomic 5
      cDNA 461
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1727, MGI:2143302
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 22
      Gene Ontology 26
      Phenotypes 35
    • Earliest
      J:8318 Saris CJ, et al., The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats. Cell. 1986 Jul 18;46(2):201-12
    • Latest
      J:347712 He J, et al., Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1. Int J Biol Sci. 2024;20(5):1707-1728
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory