Calm1 MGI Mouse Gene Detail - MGI:88251

Symbol

Calm1
Name

calmodulin 1

Feature Type

protein coding gene
IDs

MGI:88251
NCBI Gene: 12313
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr12:100165694-100176073 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 50.43 cM
Mapping Data

7 experiments

SNPs within 2kb

242 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88251	protein coding gene	Chr12:100165694-100176083 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020017	protein coding gene	Chr12:101667549-101677917 (+)
A/J	MGP_AJ_G0019972	protein coding gene	Chr12:97844543-97854913 (+)
AKR/J	MGP_AKRJ_G0019948	protein coding gene	Chr12:100494170-100504546 (+)
BALB/cJ	MGP_BALBcJ_G0019958	protein coding gene	Chr12:98189088-98199456 (+)
C3H/HeJ	MGP_C3HHeJ_G0019760	protein coding gene	Chr12:101031168-101041538 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020407	protein coding gene	Chr12:104806234-104816595 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018021	protein coding gene	Chr12:94817343-94827713 (+)
CAST/EiJ	MGP_CASTEiJ_G0019306	protein coding gene	Chr12:96144738-96155103 (+)
CBA/J	MGP_CBAJ_G0019732	protein coding gene	Chr12:108693820-108704190 (+)
DBA/2J	MGP_DBA2J_G0019843	protein coding gene	Chr12:97280136-97291635 (+)
FVB/NJ	MGP_FVBNJ_G0019832	protein coding gene	Chr12:96000448-96010849 (+)
LP/J	MGP_LPJ_G0019919	protein coding gene	Chr12:101503973-101514341 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019874	protein coding gene	Chr12:112285352-112295720 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020436	protein coding gene	Chr12:100062238-100072606 (+)
PWK/PhJ	MGP_PWKPhJ_G0019070	protein coding gene	Chr12:91914960-91925949 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018866	protein coding gene	Chr12:94244920-94257335 (+)
WSB/EiJ	MGP_WSBEiJ_G0019360	protein coding gene	Chr12:100917020-100928654 (+)

Human Ortholog

CALM1, calmodulin 1

Vertebrate Orthologs

10

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CALM1, calmodulin 1
Synonyms

CALML2, caM, CAM2, CAM3, CAMB, CAMC, CAMI, CAMIII, CPVT4, DD132, LQT14, PHKD, PHKD1
Links

HGNC:1442

NCBI Gene ID: 801

neXtProt AC: NX_P0DP23, NX_P0DP24, NX_P0DP25

UniProt: P0DP23
Chr Location

14q32.11; chr14:90396502-90408268 (+) GRCh38

MGI Vertebrate Homology

Calm1 stringent orthology
1 human;1 mouse;3 rat;6 zebrafish
HCOP

vertebrate homology predictions: CALM1
Gene Tree

Calm1

Diseases

2 with human CALM1 associations

				Human Disease	Mouse Models
				catecholaminergic polymorphic ventricular tachycardia 4 IDs catecholaminergic polymorphic ventricular tachycardia 4 DOID:0060678 ICD10CM:I47.2 OMIM:614916
				long QT syndrome 14 IDs long QT syndrome 14 DOID:0110655 ICD10CM:I45.8 OMIM:616247

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Chemically induced (other)

1
Endonuclease-mediated

8
Gene trapped

21
Targeted

3
Transgenic

1
Genomic Mutations

1 involving Calm1
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an amino acid substitution show small body size at a young age but become obese as they age and show hyperactivity, increased exploration in new environment, increased aerobic running capacity, and a slight increase in female heart rate.

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All GO Annotations

148
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

859
Tissues

131
cDNA Data

53
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CALML3

Xenbase calm1

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All Sequences

91
RefSeq

4
UniProt

1
CCDS

CCDS36523.1, CCDS83995.1

Ensembl

ENSMUSG00000001175 (Evidence)
NCBI Gene

12313

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001175	Ensembl Gene Model \| MGI Sequence Detail	10380	C57BL/6J	± kb
transcript	ENSMUST00000110082	Ensembl \| MGI Sequence Detail	4115	Not Applicable
polypeptide	ENSMUSP00000105709	Ensembl \| MGI Sequence Detail	149	Not Applicable

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UniProt

1 Sequence

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All nucleic 62

cDNA 55

Primer pair 5

Other 2

Microarray probesets 7

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MGD-MRK-1734, MGI:2144778, MGI:2144797, MGI:2144834, MGI:2144926

Summaries

All 119

Developmental Gene Expression 16

Gene Ontology 15

Phenotypes 14
Earliest

J:9357 Kluxen FW, et al., Opposite regulation of the mRNAs for parvalbumin and p19/6.8 in myotonic mouse muscle. Eur J Biochem. 1988 Sep 1;176(1):153-8
Latest

J:345934 Wren LM, et al., Sex and Gene Influence Arrhythmia Susceptibility in Murine Models of Calmodulinopathy. Circ Arrhythm Electrophysiol. 2023 Sep;16(9):e010891

TSS for Calm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114693	Chr12:100165768-100165773 (+)	77 bp
Tssr114694	Chr12:100165778-100165797 (+)	94 bp
Tssr114695	Chr12:100165806-100165811 (+)	115 bp
Tssr114696	Chr12:100165820-100165837 (+)	135 bp
Tssr114697	Chr12:100165853-100165857 (+)	161 bp
Tssr114698	Chr12:100169867-100169881 (+)	4,180 bp
Tssr114699	Chr12:100169892-100169932 (+)	4,218 bp
Tssr114700	Chr12:100171867-100171920 (+)	6,200 bp
Tssr114701	Chr12:100172351-100172368 (+)	6,666 bp
Tssr114702	Chr12:100172373-100172398 (+)	6,692 bp
Tssr114703	Chr12:100172407-100172424 (+)	6,722 bp
Tssr114704	Chr12:100172684-100172718 (+)	7,007 bp
Tssr114705	Chr12:100172798-100172837 (+)	7,124 bp
Tssr114706	Chr12:100172860-100172895 (+)	7,184 bp
Tssr114707	Chr12:100172970-100173025 (+)	7,304 bp
Tssr114708	Chr12:100173631-100173647 (+)	7,945 bp
Tssr114709	Chr12:100173828-100173845 (+)	8,143 bp
Tssr114710	Chr12:100174483-100174498 (+)	8,797 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24