Cat2 Gene Detail

Summary

• Symbol
  Cat2
• Name
  dominant cataract 2
• Synonyms
  Cat-2, nuclear and zonular cataract, Nzc, Rop, Scat

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:88272
  NCBI Gene: 111335
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 1, Syntenic
• Mapping Data
  9 experiments

Human Diseases

• Diseases
  1 with Cat2 mouse models

Human Disease

Mouse Models

cataract

IDs

cataract      

DOID:83
ICD10CM:H26
ICD9CM:366.8
OMIM:601371
OMIM:PS116200
UMLS_CUI:C0029531

View 1 model

Mouse Models

Human Disease Modeled: cataract

Allelic Composition	Genetic Background	Reference	Phenotypes
Cat2no2/Cat2+	DBA/2-Cat2^no2	J:16569	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  3 phenotype references
  

• All Mutations and Alleles
  2
• Chemically and radiation induced
  1
• Chemically induced (ENU)
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice heterozygous for an ENU-induced allele exhibit cataracts.

Expression

• Other Vertebrate Links
  Xenbase cat2

Sequences &
Gene Models

• NCBI Gene
  111335

Other
Accession IDs

MGD-MRK-12908, MGD-MRK-12957, MGD-MRK-14009, MGD-MRK-14300, MGD-MRK-1768, MGD-MRK-1770, MGD-MRK-9358

References

• Summaries
  All 29

  Diseases 1

  Phenotypes 3
• Earliest
  J:6481 Oda S, et al., Impaired development of lens fibers in genetic microphthalmia, eye lens obsolescence, Elo, of the mouse. Exp Eye Res. 1980 Dec;31(6):673-81
• Latest
  J:90087 Graw J, et al., Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse. Invest Ophthalmol Vis Sci. 2004 Apr;45(4):1202-13