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Cbr1 Gene Detail
Summary
  • Symbol
    Cbr1
  • Name
    carbonyl reductase 1
  • Synonyms
    CR
  • Feature Type
    protein coding gene
  • IDs
    MGI:88284
    NCBI Gene: 12408
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:93404752-93407226 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 54.53 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88284
 protein coding gene Chr16:93402741-93407393 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023061
 protein coding gene Chr16:94779011-94781679 (+)
A/J MGP_AJ_G0023029
 protein coding gene Chr16:90343762-90353298 (+)
AKR/J MGP_AKRJ_G0022999
 protein coding gene Chr16:93096279-93098944 (+)
BALB/cJ MGP_BALBcJ_G0023031
 protein coding gene Chr16:90874103-90877299 (+)
C3H/HeJ MGP_C3HHeJ_G0022792
 protein coding gene Chr16:93614163-93616833 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023478
 protein coding gene Chr16:97803608-97808664 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020980
 protein coding gene Chr16:88008717-88011404 (+)
CAST/EiJ MGP_CASTEiJ_G0022311
 protein coding gene Chr16:94290789-94293437 (+)
CBA/J MGP_CBAJ_G0022761
 protein coding gene Chr16:102040336-102043005 (+)
DBA/2J MGP_DBA2J_G0022895
 protein coding gene Chr16:90236888-90239552 (+)
FVB/NJ MGP_FVBNJ_G0022869
 protein coding gene Chr16:89374104-89385831 (+)
LP/J MGP_LPJ_G0022965
 protein coding gene Chr16:94466913-94469576 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022890
 protein coding gene Chr16:106440970-106445377 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023496
 protein coding gene Chr16:93605823-93637089 (+)
PWK/PhJ MGP_PWKPhJ_G0022056
 protein coding gene Chr16:90473153-90476062 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021886
 protein coding gene Chr16:93163767-93179106 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CBR1, carbonyl reductase 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBR1, carbonyl reductase 1
  • Synonyms
    CBR, hCBR1, PG-9-KR, SDR21C1
  • Links
    NCBI Gene ID: 873
    neXtProt AC: NX_P16152
    UniProt: P16152

  • Chr Location
    21q22.12; chr21:36069941-36073166 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from multigenic genotypes
    91 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    866
  • Tissues
    132
  • cDNA Data
    83
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12408 NCBI Gene Model | MGI Sequence Detail 2475 C57BL/6J ±  kb
transcript NM_007620 RefSeq | MGI Sequence Detail 1043 ZRU/MplStud  
polypeptide P48758 UniProt | EBI | MGI Sequence Detail 277 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 91
    Genomic 4
    cDNA 83
    Primer pair 2
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1787, MGI:2146635
References
more
  • Summaries
    All 134
    Developmental Gene Expression 3
    Diseases 6
    Gene Ontology 9
    Phenotypes 91
  • Earliest
    J:2142 Brookes S, et al., Localization of four human chromosome 21 genes--SOD1, ETS2, IFNAR, and CBR--to two different chromosomes in the marsupial species Macropus eugenii. Cytogenet Cell Genet. 1992;61(1):25-8
  • Latest
    J:345472 Lana-Elola E, et al., Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome. Sci Transl Med. 2024 Jan 24;16(731):eadd6883
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory