About   Help   FAQ
Cck Gene Detail
Summary
  • Symbol
    Cck
  • Name
    cholecystokinin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88297
    NCBI Gene: 12424
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:121318890-121324728 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 72.43 cM, cytoband F4
  • Mapping Data
    38 experiments
Strain
Comparison
more
  • SNPs within 2kb
    266 from dbSNP Build 142
  • Strain Annotations
    14
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88297
 protein coding gene Chr9:121318890-121324760 (-)
129S1/SvImJ ENSMUSG00200025234
 protein coding gene Chr9:118439324-118444342 (-)
A/J ENSMUSG00195026199
 protein coding gene Chr9:117602695-117607711 (-)
AKR/J ENSMUSG00220017782
 protein coding gene Chr9:118049404-118054345 (-)
BALB/cJ ENSMUSG00180027330
 protein coding gene Chr9:118139803-118144817 (-)
C3H/HeJ ENSMUSG00175017647
 protein coding gene Chr9:118383152-118388164 (-)
C57BL/6NJ ENSMUSG00215023698
 protein coding gene Chr9:118271663-118276679 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032824
 protein coding gene Chr9:116851593-116857539 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210034001
 protein coding gene Chr9:118088196-118093140 (-)
DBA/2J ENSMUSG00185015359
 protein coding gene Chr9:118422424-118427364 (-)
FVB/NJ ENSMUSG00205013731
 protein coding gene Chr9:118271454-118276466 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230031416
 protein coding gene Chr9:118578471-118583487 (-)
NOD/ShiLtJ ENSMUSG00190013702
 protein coding gene Chr9:118035662-118040678 (-)
NZO/HlLtJ ENSMUSG00225023682
 protein coding gene Chr9:118842715-118847731 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CCK, cholecystokinin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCK, cholecystokinin
  • Links
    NCBI Gene ID: 885
    UniProt: P06307

  • Chr Location
    3p22.1; chr3:42257823-42266185 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CCK associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    214 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice for one allele exhibit a significant decrease in prepulse inhibition while mice for another mutation appear normal but have increased enzyme levels of pancreatic amylase.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1497
  • Tissues
    272
  • cDNA Data
    43
  • Literature Summary
    88
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12424 NCBI Gene Model | MGI Sequence Detail 5839 C57BL/6J ±  kb
    transcript NM_001284508 RefSeq | MGI Sequence Detail 822 ZRU/MplStud  
    polypeptide P09240 UniProt | EBI | MGI Sequence Detail 115 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      Genomic 8
      cDNA 44
      Primer pair 5
      Other 9
      Antibodies 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1804
    References
    more
    • Summaries
      All 391
      Developmental Gene Expression 88
      Gene Ontology 11
      Phenotypes 214
    • Earliest
      J:8001 Friedman J, et al., Differential expression of the mouse cholecystokinin gene during brain and gut development. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5593-7
    • Latest
      J:390314 Chen W, et al., Synaptic output from suprachiasmatic nucleus cholecystokinin neurons regulates locomotor rhythmicity. Front Neurosci. 2026;20:1882096
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory