| Human Disease | Mouse Models | ||||
|---|---|---|---|---|---|
|
IDs
|
||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
|||||
|
IDs
|
early conceptus |
embryo ectoderm |
embryo endoderm |
embryo mesoderm |
embryo mesenchyme |
extraembryonic component |
alimentary system |
auditory system |
branchial arches |
cardiovascular system |
connective tissue |
endocrine system |
exocrine system |
hemolymphoid system |
integumental system |
limbs |
liver and biliary system |
musculoskeletal system |
nervous system |
olfactory system |
reproductive system |
respiratory system |
urinary system |
visual system |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Transcription Start Site | Location | Distance from Gene 5'-end |
| Tssr63378 | Chr6:127129421-127129437 (-) | -273 bp |
| Tssr63377 | Chr6:127128007-127128018 (-) | 1,143 bp |
| Tssr63376 | Chr6:127127995-127128002 (-) | 1,157 bp |
| Tssr63375 | Chr6:127127959-127127977 (-) | 1,188 bp |
| Tssr63374 | Chr6:127127626-127127639 (-) | 1,523 bp |
| Tssr63373 | Chr6:127126615-127126626 (-) | 2,535 bp |
| Tssr63372 | Chr6:127126600-127126613 (-) | 2,549 bp |
| Tssr63371 | Chr6:127126575-127126590 (-) | 2,573 bp |
| Tssr63370 | Chr6:127125745-127125787 (-) | 3,390 bp |
| Tssr63369 | Chr6:127125713-127125737 (-) | 3,431 bp |
| Tssr63368 | Chr6:127125684-127125707 (-) | 3,460 bp |
| Tssr63367 | Chr6:127119233-127119241 (-) | 9,919 bp |
| Tssr63366 | Chr6:127116184-127116214 (-) | 12,957 bp |
| Tssr63365 | Chr6:127107243-127107274 (-) | 21,897 bp |
| Tssr63364 | Chr6:127107144-127107166 (-) | 22,001 bp |
| Tssr63363 | Chr6:127106252-127106281 (-) | 22,889 bp |
| Tssr63362 | Chr6:127106135-127106146 (-) | 23,015 bp |
| Tssr63361 | Chr6:127105783-127105796 (-) | 23,366 bp |
| Tssr63360 | Chr6:127105717-127105729 (-) | 23,433 bp |
| Tssr63359 | Chr6:127102788-127102805 (-) | 26,359 bp |
| Tssr63358 | Chr6:127102764-127102781 (-) | 26,383 bp |
| Tssr63357 | Chr6:127102593-127102604 (-) | 26,557 bp |
| Tssr63356 | Chr6:127102477-127102495 (-) | 26,670 bp |
| QTL | Genetic Location* | Genome Location (GRCm39) | Reference | QTL Note |
| Pas1 | Chr6, 78.22 cM | J:78525 | Microarray gene expression analysis was used to identify candidate genes for tumor resistant and tumor susceptibility QTLs Par8,2,3,4 and and Pas1-4, respectively. Transcripts found within the flanking markers of each QTL were identified and matched to transcripts from Affymetrix probe sets. RNA from A/J, BALB/cJ, C57BL/6J, and SM/J were used for analysis. Pas1 is located between 48.2 cM and 75 cM on mouse Chromosome 6 and was identified in a cross between A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are hes related protein (**Note- this gene is not found in MGD), Ppih (cyclophilin H **Note-this gene is positioned on mouse Chromosome 4 in MGD), Ptpro, Mglap, Recql, and Bcat1 (ECA39). Other candidate genes identified via differential expression are Ccnd2 (cyclin D2) and high mobility group protein 2A,4 (**Note-this gene is not found in MGD). K-ras, a positional candidate gene, did not show significantly different expression between A/J and C57BL/6J. Pas2 is located between 17 cMand 23.2 cM on mouse Chromosome 17 and was identified in crosses involving A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are Notch4, Hnrpk (**Note-this gene is positioned on mouse Chromosome 13 in MGD), and Enpp4. Other candidate genes identified via differential expression are Cdc5l, Tapbp (tapasin), H2-Ke2, Rbx1 (regulator of cullins 1 **Note- this gene is found on mouse Chromosome 15 in MGD), Psors1c2, H2-Ke6, and H2-M9. Positional candidate genes Tnf (Tnfa) and Lta (Tnfb) did not show significantly different expression between A/J and C57BL/6J. Pas3 is located between 2 cM and 25 cM on mouse Chromosome 19 and was identified in a cross between A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are golgi specific Gbf1 (brefeldin A resistance factor 1) and Sema4g. Other candidate genes identified via differential expression are Pdcd4, Adrb1, and Cdc25l. Pas4 is located between 42 cM and 72 cM on mouse Chromosome 9 and was identified in a cross between A/J and C57BL/6J. Candidate oncogenic genes identified by microarray analysis are Nck1, Pthr1, and Topbp1. Candidate tumor suppressor genes for Pas4 are G protein alpha I 2 (**Note-this gene is not found in MGD), Cdk5 (**Note-this gene is positioned on mouse Chromosome 5 in MGD), Smarcd3 (**Note-this gene is positioned on mouse Chromosome 5 in MGD), and Nckipsd. Another candidate gene identified via differential expression is Stag1. Par1 is located between 37 cM and 59 cM on mouse Chromosome 11 and was identified in a cross between A/J and SM/J. Candidate oncogenic genes identified by microarray analysis are Alox12 (12-lipoxygenase), Zfp617 (zinc finger protein s11-6), Grn, and Rpl29 (**Note-this gene is positioned on mouse Chromosome 9 in MGD). A tumor suppressor candidate gene for Par1 is Spop. 02.05.2016 Curator Note: Because Par1 was originally mapped in J:32079 using an (A/J x M. spretus) x C57BL/6J interspecific backcross, which differs from the cross used here, we have equated this QTL with Par8 which was mapped using A/J and SM/J mice, see J:41849. Par2 is located between 32 cM and 57 cM on mouse Chromosome 18 and was identified in a cross between A/J and BALB/cJ. Candidate oncogenic genes identified by microarray analysis are Adrb2, Mbd2, Htr4, Hmgb1-rs12, and Iigp1. Dcc is an expected candidate gene of Par2 but its expression pattern (A/J=high expression) is not consistent with its effect on tumor resistance/susceptibility. Mc2r is another candidate gene identified via differential gene expression between A/J and SM/J. Par3 is located between 13 cM and 44 cM on mouse Chromosome 12 and was identified in a cross between A/J and SM/J. Only one candidate oncogenic gene was identified for Par3. This is placental growth factor, Pgf. Par4 is located between 10.6 cM and 42.5 cM on mouse Chromosome 4 and was identified in a cross between A/J and BALB/cJ. Candidate tumor suppressor genes identified via differential gene expression are Cdkn2a, Egfl5, Ambp (bikunin), Pole3, Tyrp1, Ifnab, and Igfbpl1.Candidate oncogenes are T complex protein 1 alpha (**Note-this gene is not found in MGD) and Stmn1. Another candidate gene identified via differential expression between A/J and SM/J is Ptprd. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
Analysis Tools
